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401487 IKK-2 Inhibitor VIII - CAS 406208-42-2 - Calbiochem

The IKK-2 Inhibitor VIII, also referenced under CAS 406208-42-2, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-(4-piperidinyl)-3-pyridinecarbonitrile, ACHP

Primary Target: IKK-2
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401487
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Overview

Key Spec Table

CAS #Empirical Formula
406208-42-2C₂₁H₂₄N₄O₂

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401487-1MG
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      Description
      OverviewA cell-permeable piperidinyl-pyridine compound that acts as a selective inhibitor of IKK-2 activity (IC50 = 8.5 and 250 nM for IKK-2 and IKK-1, respectively) with little effect towards IKK-3, Syk, and MKK4 (IC50 >20 µM). Exhibits good aqueous solubility (0.12 mg/ml in pH 7.4 isotonic buffer) and potent activity in various cellular assays in vitro (IC50 <150 nM). Shown to be orally bioavailable both in rats and mice (BA = 60% and 16%, respectively) and effectively inhibit arachidonic acid-induced swelling in a murine ear edema model in vivo.
      Catalogue Number401487
      Brand Family Calbiochem®
      Synonyms2-Amino-6-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-4-(4-piperidinyl)-3-pyridinecarbonitrile, ACHP
      References
      ReferencesMurata, T., et al. 2004. Bioorg. Med. Chem. Lett. 14, 4019.
      Product Information
      CAS number406208-42-2
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₂₁H₂₄N₄O₂
      Chemical formulaC₂₁H₂₄N₄O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetIKK-2
      Primary Target IC<sub>50</sub>8.5 and 250 nM for IKK-2 and IKK-1, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      401487-1MG 04055977212044