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361551 GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
740841-15-0C₁₈H₁₂BrN₃O₃

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361551-1MG
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      Description
      OverviewAn acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3α/β (IC50 = 10 nM) over Cdk5/p25, Cdk2/A and Cdk1/B (IC50 = 2.4 µM, 4.3 µM and 63 µM, respectively). Weakly affects the activities of Cdk4/D1 and many other kinases (IC50 ≥ 10 µM). Also acts as an aryl hydrocarbon receptor agonist in both yeast (EC50 ≥ 0.1 µM) and mammalian (EC50 = 0.16 µM) reporter systems.
      Catalogue Number361551
      Brand Family Calbiochem®
      SynonymsBIO-Acetoxime, (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-acetoxime
      References
      ReferencesKnockaert, M., et al. 2004. Oncogene 23, 4400.
      Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
      Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
      Product Information
      CAS number740841-15-0
      ATP CompetitiveN
      FormDark purple solid
      Hill FormulaC₁₈H₁₂BrN₃O₃
      Chemical formulaC₁₈H₁₂BrN₃O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetGSK-3α/β
      Primary Target IC<sub>50</sub>10 nM against GSK-3α/β
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      361551-1MG 04055977214093