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343020 Flt-3 Inhibitor - CAS 301305-73-7 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
301305-73-7C₁₈H₂₀N₂O₄S

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343020-5MG
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      Description
      OverviewA cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor (IC50 = 42 nM) with little effect against a panel of 22 other kinases (IC50 ≥3 µM). Shown to exhibit antiproliferative properties against the human acute myelogenous leukemia cell line MV4-11 (IC50 = 340 nM) expressing constitutively active Flt-3.
      Catalogue Number343020
      Brand Family Calbiochem®
      References
      ReferencesPatch, R.J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3282.
      Product Information
      CAS number301305-73-7
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₈H₂₀N₂O₄S
      Chemical formulaC₁₈H₂₀N₂O₄S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetFlt-3
      Primary Target IC<sub>50</sub>42 nM against Flt-3
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      343020-5MG 04055977195019