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262015 DNA Base Excision Repair Pathway Inhibitor - CAS 6960-45-8 - Calbiochem

The DNA Base Excision Repair Pathway Inhibitor, also referenced under CAS 6960-45-8, controls the biological activity of APE1 (human apurinic/apyrimidinic endonuclease.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7-Nitroindole-2-carboxylic acid, CRT0044876

Primary Target: APE 1
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262015
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
6960-45-8C₉H₆N₂O₄

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      Description
      OverviewA cell-permeable, potent, specific, and nontoxic inhibitor of the DNA repair enzyme, APE1 (human apurinic/apyrimidinic endonuclease; IC50 = ~3 µM). Shown to target the APE1 active site and inhibit its 3′-phosphodiesterase and 3′-phosphatase activities. Exhibits minimal effects on endonuclease IV, BamH1 restriction endonuclease, or topoisomerase I even at concentration as high as 100 µM. Also shown to potentiate the cytotoxicity of several DNA damaging agents, such as MMS, temozolomide, Zeocin, and H2O2 in HeLa, HT1080, and MDA-MB-231 cells.
      Catalogue Number262015
      Brand Family Calbiochem®
      Synonyms7-Nitroindole-2-carboxylic acid, CRT0044876
      References
      ReferencesMadhusudan, S., et al. 2005. Nucl. Acids Res. 33, 4711.
      Product Information
      CAS number6960-45-8
      ATP CompetitiveN
      FormTan solid
      Hill FormulaC₉H₆N₂O₄
      Chemical formulaC₉H₆N₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAPE 1
      Primary Target IC<sub>50</sub>~3 µM against APE1 (human apurinic/apyrimidinic endonuclease
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      262015-25MG 04055977216974

      Documentation

      DNA Base Excision Repair Pathway Inhibitor - CAS 6960-45-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      DNA Base Excision Repair Pathway Inhibitor - CAS 6960-45-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      262015

      References

      Reference overview
      Madhusudan, S., et al. 2005. Nucl. Acids Res. 33, 4711.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-August-2018 JSW
      Synonyms7-Nitroindole-2-carboxylic acid, CRT0044876
      DescriptionA cell-permeable, potent, specific, and nontoxic inhibitor of the DNA repair enzyme, APE1 (human apurinic/apyrimidinic endonuclease; IC50 ~3 µM). Shown to target the APE1 active site and inhibit its 3′-phosphodiesterase and 3′-phosphatase activities. Exhibits minimal effects on endonuclease IV, BamH1 restriction endonuclease, or topoisomerase I even at concentration as high as 100 µM. Also shown to potentiate the cytotoxicity of several DNA damaging agents, such as MMS, temozolomide, Zeocin, and H2O2 in HeLa, HT1080, and MDA-MB-231 cells.
      FormTan solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number6960-45-8
      Chemical formulaC₉H₆N₂O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesMadhusudan, S., et al. 2005. Nucl. Acids Res. 33, 4711.