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264150 Caspase-3 Substrate IV, Fluorogenic - CAS 1177935-21-5 - Calbiochem

Fluorogenic caspase-3 substrate.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-DEVD-AFC

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264150
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Overview

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264150-1MG
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      		 Plastic ampoule 1 mg
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      Description
      OverviewFluorogenic caspase-3 substrate. Also acts as a substrate for granzyme B-processed ICE-LAP3. Reaction can be monitored by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore. Also a substrate for caspase-6, caspase-7, caspase-8, and caspase-10.
      Catalogue Number264150
      Brand Family Calbiochem®
      SynonymsZ-DEVD-AFC
      References
      ReferencesKeramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Kluck, R.M., et al. 1997. Science 275, 1132.
      Talanian, J., et al. 1997. J. Biol. Chem. 272, 9677.
      Chinnaiyan, A.M., et al. 1996. Curr. Biol. 6, 897.
      Nicholson, D.W., et al. 1995. Nature 376, 37.
      Product Information
      CAS number1177935-21-5
      ATP CompetitiveN
      FormWhite or off-white solid
      Hill FormulaC₃₆H₃₈F₃N₅O₁₄
      Chemical formulaC₃₆H₃₈F₃N₅O₁₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFluorogenic caspase-3 substrate.
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Emission max.
      Excitation max.
      Peptide SequenceZ-Asp-Glu-Val-Asp-AFC
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      264150-1MG 04055977198409

      Documentation

      Caspase-3 Substrate IV, Fluorogenic - CAS 1177935-21-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Caspase-3 Substrate IV, Fluorogenic - CAS 1177935-21-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      264150

      References

      Reference overview
      Keramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Kluck, R.M., et al. 1997. Science 275, 1132.
      Talanian, J., et al. 1997. J. Biol. Chem. 272, 9677.
      Chinnaiyan, A.M., et al. 1996. Curr. Biol. 6, 897.
      Nicholson, D.W., et al. 1995. Nature 376, 37.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-March-2011 RFH
      SynonymsZ-DEVD-AFC
      DescriptionFluorogenic CPP-32/apopain substrate. Also acts as a substrate for granzyme B-processed ICE-LAP3. Reaction can be monitored by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore. Excitation max: ~400 nm; emission max: ~505 nm.
      FormWhite or off-white solid
      CAS number1177935-21-5
      Chemical formulaC₃₆H₃₈F₃N₅O₁₄
      Peptide SequenceZ-Asp-Glu-Val-Asp-AFC
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKeramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Kluck, R.M., et al. 1997. Science 275, 1132.
      Talanian, J., et al. 1997. J. Biol. Chem. 272, 9677.
      Chinnaiyan, A.M., et al. 1996. Curr. Biol. 6, 897.
      Nicholson, D.W., et al. 1995. Nature 376, 37.