264155 Sigma-AldrichCaspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem
Caspase-3 Inhibitor II, CAS 210344-95-9, is a cell-permeable, potent, and irreversible inhibitor of caspase-3 (IC50 = 130 nM). Also inhibits caspase-6, caspase-7, caspase-8, and caspase-10.
More>> Caspase-3 Inhibitor II, CAS 210344-95-9, is a cell-permeable, potent, and irreversible inhibitor of caspase-3 (IC50 = 130 nM). Also inhibits caspase-6, caspase-7, caspase-8, and caspase-10. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Z-D(OMe)E(Ome)VD(OMe)-FMK
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 210344-95-9 | C₃₀H₄₁FN₄O₁₂ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 264155-1MG |
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Plastic ampoule | 1 mg |
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| 264155-250UG |
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Plastic ampoule | 250 μg |
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| Description | |
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| Overview | A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/75 µl) solution of Z-DEVD-FMK (Cat. No. 264156) in DMSO is also available. |
| Catalogue Number | 264155 |
| Brand Family | Calbiochem® |
| Synonyms | Z-D(OMe)E(Ome)VD(OMe)-FMK |
| Product Information | |
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| CAS number | 210344-95-9 |
| ATP Competitive | N |
| Form | White to slightly brown solid |
| Hill Formula | C₃₀H₄₁FN₄O₁₂ |
| Chemical formula | C₃₀H₄₁FN₄O₁₂ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ200 |
| Biological Information | |
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| Primary Target | caspase-3, caspase-6, caspase-7, caspase-8, caspase-10 |
| Purity | ≥90% by TLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Peptide Sequence | Z-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 264155-1MG | 04055977198447 |
| 264155-250UG | 04055977198454 |
Documentation
Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem SDS
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Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 264155 |
References
| Reference overview |
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| Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641. Nicholson, D.W. 1996. Nature Biotech. 14, 297. Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841. Nicholson, D.W., et al. 1995. Nature 376, 37. |
Brochure
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| Caspases and other Apoptosis Related Tools Brochure |
Citations
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| Data Sheet | ||||||||||||||||||||||||||||||||
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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