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534360 Autophagy Inhibitor VII - Calbiochem

A cell-permeable, potent lysosome targeted autophagy inhibitor with reduced toxicity. OM: Supplied as HCl salt. After EA, will suitably recommend the changes.

Autophagy Inhibitor VII - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-Chloro-N-(1-ethylpiperidin-4-yl)-1,2,3,4-tetrahydroacridin-9-amine, Acridinamine 33, Tetrahydroacridine 33, THA33

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534360
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₀H₂₆ClN₃

Pricing & Availability

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      		 25 mg
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      Description
      OverviewA cell-permeable tetrahydroacridinamine (THA) derived compound that potently suppresses autophagy (EC = 250 nM) with reduced toxicity (LD50 = 27 µM) in U2OS cells. Shown to induce lysosome deacidification and increase LC3-II protein accumulation. Displays attractive biophysical properties.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number534360
      Brand Family Calbiochem®
      Synonyms6-Chloro-N-(1-ethylpiperidin-4-yl)-1,2,3,4-tetrahydroacridin-9-amine, Acridinamine 33, Tetrahydroacridine 33, THA33
      DescriptionAutophagy Inhibitor VII
      References
      ReferencesWang, T., et al. 2015. J. Med. Chem. 58, 3025.
      Product Information
      FormWhite to pale yellow solid
      FormulationSupplied as HCl salt.
      Hill FormulaC₂₀H₂₆ClN₃
      Chemical formulaC₂₀H₂₆ClN₃
      Hygroscopic Hygroscopic
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      5343600001 04054839059254

      Documentation

      Autophagy Inhibitor VII - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Wang, T., et al. 2015. J. Med. Chem. 58, 3025.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-October-2024 JSW
      Synonyms6-Chloro-N-(1-ethylpiperidin-4-yl)-1,2,3,4-tetrahydroacridin-9-amine, Acridinamine 33, Tetrahydroacridine 33, THA33
      DescriptionA cell-permeable tetrahydroacridinamine (THA) derived compound that potently suppresses autophagy (EC = 250 nM) with reduced toxicity (LD50 = 27 µM) in U2OS cells. Shown to induce lysosome deacidification and increase LC3-II protein accumulation. Displays attractive biophysical properties.
      FormWhite to pale yellow solid
      FormulationSupplied as HCl salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₀H₂₆ClN₃
      Purity≥98% by HPLC
      SolubilityH₂O (50 mg/ml) or DMSO (1.6 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesWang, T., et al. 2015. J. Med. Chem. 58, 3025.