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178270 Apamin, Bee Venom - CAS 24345-16-2 - Calbiochem

Polypeptide neurotoxin known to pass through the blood-brain barrier.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CNCKAPETALCARRCQQH-NH₂

Primary Target: AHP-type Ca2+-activated K+ channel
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178270
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
24345-16-2C₇₉H₁₃₁N₃₁O₂₄S₄

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      Description
      OverviewPolypeptide neurotoxin known to pass through the blood-brain barrier. Blocks the AHP-type Ca2+-activated K+ channel; does not block the TEA and voltage-sensitive Ca2+-activated K+ channel. Reported to induce neurodegeneration of Purkinje cells in rat brain. Known to induce the secretion of prolactin in a dose-dependent manner.
      Catalogue Number178270
      Brand Family Calbiochem®
      SynonymsCNCKAPETALCARRCQQH-NH₂
      References
      ReferencesMourre, C., et al. 1997. Brain Res. 778, 405.
      Silva, E.G., et al. 1994. Br. J. Pharmacol. 113, 1022.
      Wang, X., et al. 1994. Brain Res. 662, 83.
      Product Information
      CAS number24345-16-2
      ATP CompetitiveN
      FormWhite solid with dark tan cast
      Hill FormulaC₇₉H₁₃₁N₃₁O₂₄S₄
      Chemical formulaC₇₉H₁₃₁N₃₁O₂₄S₄
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAHP-type Ca2+-activated K+ channel
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Cys¹-Asn-Cys³-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys¹¹-Ala-Arg-Arg-Cys¹⁵-Gln-Gln-His-NH₂ (disulfide bonds: 1 → 11; 3 → 15)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSCD6899900
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Acetic acid stock solutions are stable for up to 3 days at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      178270-500UG 04055977223156

      Documentation

      Apamin, Bee Venom - CAS 24345-16-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Apamin, Bee Venom - CAS 24345-16-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      178270

      References

      Reference overview
      Mourre, C., et al. 1997. Brain Res. 778, 405.
      Silva, E.G., et al. 1994. Br. J. Pharmacol. 113, 1022.
      Wang, X., et al. 1994. Brain Res. 662, 83.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-April-2008 RFH
      SynonymsCNCKAPETALCARRCQQH-NH₂
      DescriptionA polypeptide neurotoxin known to pass through the blood-brain barrier. Blocks the AHP-type Ca2+-activated K+ channel; however, it does not block the TEA and voltage-sensitive Ca2+-activated K+ channel. Known to induce the secretion of prolactin in a dose-dependent manner.
      FormWhite solid with dark tan cast
      CAS number24345-16-2
      RTECSCD6899900
      Chemical formulaC₇₉H₁₃₁N₃₁O₂₄S₄
      Peptide SequenceH-Cys¹-Asn-Cys³-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys¹¹-Ala-Arg-Arg-Cys¹⁵-Gln-Gln-His-NH₂ (disulfide bonds: 1 → 11; 3 → 15)
      Purity≥98% by HPLC
      Solubility5% Acetic Acid (2 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Acetic acid stock solutions are stable for up to 3 days at -20°C.
      Toxicity Harmful
      Merck USA index14, 725
      ReferencesMourre, C., et al. 1997. Brain Res. 778, 405.
      Silva, E.G., et al. 1994. Br. J. Pharmacol. 113, 1022.
      Wang, X., et al. 1994. Brain Res. 662, 83.