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MABN774 Anti-TDP-43 Antibody, clone DB9

Detect TDP-43 using this Anti-TDP-43 Antibody, clone DB9 validated for use in western blotting & IHC.

Anti-TDP-43 Antibody, clone DB9 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: TARDBP, TDP43 UniProt Number: Q13148
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MABN774
100 µg  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN774
      DescriptionAnti-TDP-43 Antibody, clone DB9
      Alternate Names
      • TAR DNA-binding protein 43
      • TDP-43
      • TDP43
      • TAR DNA binding protein-43
      Background InformationTAR DNA-binding protein 43 (TDP-43) belongs to the hnRNP protein family and plays an important role in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. It is involved in splicing of the apolipoprotein A-II and cystic fibrosis transmembrane gene. This protein is highly expressed in the pancreas, placenta, lung, genital tract and spleen. Mutations in TDP-43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease and Alzheimer's disease.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect TDP-43 using this Anti-TDP-43 Antibody, clone DB9 validated for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TDP-43 in human cerebellum, pancreas, and thalamus tissues.
      Biological Information
      ImmunogenThe antibody was raised against an immunogen consisting of His-tagged recombinant protein corresponding to amino acid residues 208-414 of human TDP-43.
      CloneDB9
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TARDBP
      • TDP43
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~43 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in SH-SY-5Y cell lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected TDP-43 in 10 µg of SH-SY-5Y cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN774 04053252946059

      Documentation

      Anti-TDP-43 Antibody, clone DB9 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-TDP-43 Antibody, clone DB9 Certificates of Analysis

      TitleLot Number
      Anti-TDP-43, clone DB9 - 3205457 3205457
      Anti-TDP-43, clone DB9 - 3483445 3483445
      Anti-TDP-43, clone DB9 - 3604765 3604765
      Anti-TDP-43, clone DB9 - 3724694 3724694
      Anti-TDP-43, clone DB9 - 3839157 3839157
      Anti-TDP-43, clone DB9 - 3879502 3879502
      Anti-TDP-43, clone DB9 - 4108272 4108272
      Anti-TDP-43, clone DB9 - 4163450 4163450
      Anti-TDP-43, clone DB9 - Q2364942 Q2364942
      Anti-TDP-43, clone DB9 -2796263 2796263
      Show more

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies