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AB4254 Anti-Proteinase-Activated Receptor 2 Antibody, NT, extracellular

This Anti-Proteinase-Activated Receptor 2 Antibody, N-terminal, extracellular is validated for use in IH(P) for the detection of Proteinase-Activated Receptor 2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Inflammation & Autoimmune Mechanisms Gene Symbol: F2RL1, PAR-2, PAR2, GPR11 UniProt Number: P55085
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AB4254
50 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB4254
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Proteinase-Activated Receptor 2 Antibody, NT, extracellular
      Alternate Names
      • PAR-2
      Background InformationThe Proteinase-activated receptor 2 (PAR2) is a member of the proteinase-activated receptor subfamily. It is activated through proteolytic exposure of an occult tethered ligand by trypsin and trypsin-like proteases. This is in contrast to other members of the subfamily which are activated by the protease thrombin. PAR2 has been implicated in acute inflammatory response, asthma, and pain transmission. PAR2 expression has been documented in the periphery. ESTs have been isolated from adrenal, brain, breast, heart/melanocyte/uterus, kidney, lung, and vessel libraries.
      References
      Product Information
      FormatAffinity Purified
      PresentationPeptide-affinity purified immunoglobulin. Liquid in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Proteinase-Activated Receptor 2 Antibody, N-terminal, extracellular is validated for use in IH(P) for the detection of Proteinase-Activated Receptor 2.
      Key Applications
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry (formalin-fixed, paraffin-embedded tissues)

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to a sequence within the N-terminal extracellular domain of human PAR2. The immunogen has 70% homology with mouse and 60% homology with rat.
      EpitopeN-terminal, extracellular
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes human PAR2. The specificity of this antibody has been confirmed by IHC staining of human pancreas.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCoagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.
      Gene Symbol
      • F2RL1
      • PAR-2
      • PAR2
      • GPR11
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P55085 # Receptor for trypsin and trypsin-like enzymes coupled to G proteins that stimulate phosphoinositide hydrolysis. May have a role in the regulation of vascular tone.
      SIZE: 397 amino acids; 44126 Da
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon. Moderate expression is detected in many organs, but none in brain or skeletal muscle.
      PTM: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
      SIMILARITY: SwissProt: P55085 ## Belongs to the G-protein coupled receptor 1 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -70°C in undiluted aliquots for up to 12 months from date of receipt. May be stored at 2-8°C for short term use. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB4254 04053252516115

      Documentation

      Anti-Proteinase-Activated Receptor 2 Antibody, NT, extracellular SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Proteinase-Activated Receptor 2 Antibody, NT, extracellular Certificates of Analysis

      TitleLot Number
      RABBIT ANTI- PROTEINASE-ACTIVATED RECEPTOR 2 POLYCLONAL ANTIBODY - 2387491 2387491
      RABBIT ANTI- PROTEINASE-ACTIVATED RECEPTOR 2 POLYCLONAL ANTIBODY 3079585
      RABBIT ANTI- PROTEINASE-ACTIVATED RECEPTOR 2 POLYCLONAL ANTIBODY 2923372
      RABBIT ANTI- PROTEINASE-ACTIVATED RECEPTOR 2 POLYCLONAL ANTIBODY 2906459
      RABBIT ANTI- PROTEINASE-ACTIVATED RECEPTOR 2 POLYCLONAL ANTIBODY 2896177
      RABBIT ANTI- PROTEINASE-ACTIVATED RECEPTOR 2 POLYCLONAL ANTIBODY - 2042698 2042698
      RABBIT ANTI- PROTEINASE-ACTIVATED RECEPTOR 2 POLYCLONAL ANTIBODY - 2172679 2172679

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies