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ABE125 Anti-PRMT7 Antibody

Anti-PRMT7 Antibody detects level of PRMT7 & has been published & validated for use in PRMT7.

Anti-PRMT7 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Nuclear Receptors Gene Symbol: PRMT7 UniProt Number: Q9NVM4
ABE125
200 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE125
      DescriptionAnti-PRMT7 Antibody
      Alternate Names
      • Protein arginine N-methyltransferase 7
      • Histone-arginine N-methyltransferase PRMT7
      • Myelin basic protein]-arginine N-methyltransferase PRMT7
      Background InformationPRMT7, also known as Protein arginine N-methyltransferase 7, Histone-arginine N-methyltransferase PRMT7 or Myelin basic protein-arginine N-methyltransferase PRMT7, and encoded by the gene PRMT7/KIAA1933, is an arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. PRMT7 specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins SmD1 (SNRPD1) and SmD3 (SNRPD3). Such methylation is required for the assembly and biogenesis of snRNP core particles. PRMT7 also mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s, and it plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s and thus leading to the recruitment of DNA methyltransferases to those sites. Finally, PRMT7 may also play a role in embryonic stem cell (ESC) pluripotency and is able to methylate histone H2A and myelin basic protein (MBP).
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit Polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-PRMT7 Antibody detects level of PRMT7 & has been published & validated for use in PRMT7.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human PRMT7
      Epitopeunknown
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody is expected to cross react with all isoforms based upon immunogen design.
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Chimpanzee, Horse, Feline, Bovine, Ferret based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PRMT7
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~75 kDa observed. Uniprot describes four isoforms at 79 kDa (Isoform 1), 62 kDa (Isoform 2), 73 kDa (Isoform 3), and 64 kDa (Isoform 4).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in U2OS nuclear extract.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected PRMT7 in 10 µg of U2OS nuclear extract.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE125 04053252961113

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