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AB5400 Anti-GFR α3 Antibody

This Anti-GFR α3 Antibody is validated for use in WB, IH for the detection of GFR α3.

Anti-GFR α3 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurochemistry & Neurotrophins Gene Symbol: GFRA3, ORFNames=UNQ339/PRO538/PRO3664, GFR-alpha-3, GFRa-3 UniProt Number: O60609
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AB5400
50 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWB, IHCRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB5400
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-GFR α3 Antibody
      References
      Product Information
      FormatSerum
      PresentationRabbit serum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile distilled water. Centrifuge if necessary to remove any residue.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-GFR α3 Antibody is validated for use in WB, IH for the detection of GFR α3.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern blot: 1:500

      Immunohistochemistry: 1:500-1:1,000

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenAn eleven amino acid peptide corresponding to the N-terminus of the mouse GFR(3 protein.
      HostRabbit
      SpecificityGFRa3. No reactivity with its homologues.
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin.
      Gene Symbol
      • GFRA3
      • ORFNames=UNQ339/PRO538/PRO3664
      • GFR-alpha-3
      • GFRa-3
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O60609 # Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.
      SIZE: 400 amino acids; 44511 Da
      SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
      TISSUE SPECIFICITY: Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system.
      PTM: N-glycosylated.
      SIMILARITY: SwissProt: O60609 ## Belongs to the GDNFR family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C to -70°C for up to 6 months after date of receipt. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB5400 04053252361623