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MABC272 Anti-Annexin VI Antibody, clone 4B11.1

This Anti-Annexin VI Antibody, clone 4B11.1 is validated for use in western blotting & ICC for the detection of Annexin VI.

Anti-Annexin VI Antibody, clone 4B11.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: ANXA6, ANX6 UniProt Number: P08133
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MABC272
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, ICCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC272
      DescriptionAnti-Annexin VI Antibody, clone 4B11.1
      Alternate Names
      • Annexin A6
      • 67 kDa calelectrin
      • Annexin VI
      • Annexin-6
      • Calphobindin-II
      • CPB-II
      • Chromobindin-20
      • Lipocortin VI
      • Protein III
      • p68
      • p70
      Background InformationThe protein Annexin A6 or alternatively known as 67 kDa calelectrin, Annexin VI, Annexin-6, Calphobindin-II (CPB-II), Chromobindin-20, Lipocortin VI, Protein III, p68, or p70 and encoded by the human gene named ANXA6 or ANX6. Annexin VI is part of a large family of Annexin proteins and shares with the family the ability to bind negatively charged phospholipids in a calcium dependent manner. Localized in the plasma membrane annexins are important in many cellular functions as the provide scaffolds and play roles in vesicle transport, exocytosis, endocytosis and calcium transport and conduction. Recent research indicates that Annexin VI can interact with PKCalpha and EGFR in A431 cells to help regulate the phosphorylation of pY-EGFR and the associated activation of downstream signaling events associated with cancer. Annexin VI in normal tissue is expressed most strongly in myocardial tissue where it associates with sarcomeric α-actinin and is part of the sarcomere structure. Annexin VI also regulates terminal chondrocyte differentiation by modulating key signaling pathway activities.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Annexin VI Antibody, clone 4B11.1 is validated for use in western blotting & ICC for the detection of Annexin VI.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesWestern Blotting Analysis: 1 µg/mL from a representative lot detected Annexin VI in 10 µg of C2C12 cell lysate.

      Immunocytochemistry Analysis: A 1:50 dilution from a representative lot detected Annexin VI in HeLa and A431 cells.

      Alexa Fluor® is a registered trademark of Life Technologies®.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Annexin VI.
      Clone4B11.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ANXA6
      • ANX6
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~75 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in SH-SY5Y cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected Annexin VI in 10 µg of SH-SY5Y cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABC272 04053252965302