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07-1459 Anti-14-3-3 Antibody, 30 & 33 kDa isoforms

07-1459
100 µL  
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, M, HWBRbSerumPolyclonal Antibody
      Description
      Catalogue Number07-1459
      Replaces04-1089
      DescriptionAnti-14-3-3 Antibody, 30 & 33 kDa isoforms
      Alternate Names
      • 14-3-3 epsilon
      • 14-3-3 protein epsilon
      • mitochondrial import stimulation factor L subunit
      • protein kinase C inhibitor protein-1
      • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation
      • protein, epsilon polypeptide
      • tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide 2
      Background InformationMammals express seven distinct 14-3-3 isoforms (gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo- and hetero- dimmers, thus rendering 14-3-3 as a key multifunctional regulatory molecule. 14-3-3 isomers have been implicated in several neurological disorders: for example isoforms gamma, epsilon and beta are expressed in the cerebrospinal fluid of Creutzfeldt-Jakob patients, but not patients suffering from other neurological conditions such as Alzheimer's.
      Product Information
      FormatSerum
      Control
      • Jurkat cell lysates
      PresentationRabbit serum in liquid containing no preservatives.
      Applications
      ApplicationAnti-14-3-3 Antibody, 30 & 33 kDa isoforms is an antibody against 14-3-3 for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenSynthetic peptide corresponding to rat 14-3-3 epsilon, amino acids 208-244.
      Epitopea.a 208-244
      HostRabbit
      SpecificityPolyclonal antibody raised in rabbits using a synthetic peptide corresponding to a sequence conserved among 14-3-3 proteins. It reacts with both the 33 kD and 30 kD isoforms of
      14-3-3 proteins.
      Species Reactivity
      • Rat
      • Mouse
      • Human
      Species Reactivity NoteProven to react with human, mouse and rat.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • YWHAE
      • KCIP-1
      • MDS
      • 14-3-3E
      • MDCR
      • FLJ45465
      Purification MethodUnpurified rabbit serum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P62258 # Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
      SIZE: 255 amino acids; 29174 Da
      SUBUNIT: Homodimer. Interacts with NDEL1 (By similarity). Interacts with HCV core protein.
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
      SIMILARITY: SwissProt: P62258 ## Belongs to the 14-3-3 family.
      Molecular WeightApprox. 30 kDa, and 33 kDa
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in Jurkat cell lysates.
      Western Blot Analysis: 1:500 dilution of this lot detected 14-3-3 PROTEINS on 10 g of Jurkat lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 1 year after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Global Trade Item Number
      Catalogue Number GTIN
      07-1459 04053252328916