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172104 Anaphase-Promoting Complex Inhibitor, TAME - CAS 1784-03-8 - Calbiochem

The Anaphase-Promoting Complex Inhibitor, TAME, also referenced under CAS 1784-03-8, controls the biological activity of Anaphase-Promoting Complex. This small molecule/inhibitor is primarily used for

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Synonyms: TAME hydrochloride, APC/C Inhibitor I, APC/C-Cdc20 Interaction Inhibitor I, Cyclosome Inhibitor I

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172104
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172104-50MG
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      Description
      OverviewTAME is a potent ubiquitin ligase inhibitor that specifically blocks Anaphase-Promoting Complex (APC) activation by directly binding to APC and disrupts the IR-tail-dependent interactions between APC and its activator proteins Cdc20 or Cdh1. It stabilizes APC substrates and is shown to inhibit cyclin proteolysis in mitotic Xenopus egg extract with an IC50 = 12 µM.
      Catalogue Number172104
      Brand Family Calbiochem®
      SynonymsTAME hydrochloride, APC/C Inhibitor I, APC/C-Cdc20 Interaction Inhibitor I, Cyclosome Inhibitor I
      References
      ReferencesSackton, K.L., et al. 2014. Nature. In press.
      Zeng, X., et al. 2010. Cancer Cell 18, 382.
      Product Information
      CAS number1784-03-8
      FormWhite solid
      Hill FormulaC₁₄H₂₂N₄O₄S · HCl
      Chemical formulaC₁₄H₂₂N₄O₄S · HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥98% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      172104-50MG 04055977222906