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Buffer Detection Kit for Magnetic Beads
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171256
Sigma-AldrichAMPK Activator - CAS 849727-81-7 - Calbiochem
The AMPK Activator, also referenced under CAS 849727-81-7, modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
More>>The AMPK Activator, also referenced under CAS 849727-81-7, modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Activators/Inducers applications. Less<<
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Description
Overview
A cell-permeable furancarboxylic acid compound that activates celular AMP-activated protein kinase (AMPK) activity by inhibiting mitochondrial complex I, and thus elevating intracellular AMP level. Shown to enhance glucose uptake in L6 myocytes (EC50 = 11.7 µM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Displays negligible cytotoxicity at pharmacological doses.
Catalogue Number
171256
Brand Family
Calbiochem®
Synonyms
5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid, D942, AMPK Signaling Activator I
AMPK Activator - CAS 849727-81-7 - Calbiochem Certificates of Analysis
Title
Lot Number
171256
References
Reference overview
Kosaka, T., et al. 2005. Anal. Chem.77, 2050.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
11-April-2008 RFH
Synonyms
5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid, D942, AMPK Signaling Activator I
Description
A cell-permeable furancarboxylic acid compound that activates celular AMP-activated protein kinase (AMPK) activity by inhibiting mitochondrial complex I, and thus elevating intracellular AMP level. Shown to enhance glucose uptake in L6 myocytes (EC50 = 11.7 µM). Reduces blood glucose levels in ZDF rats in vivo (oral dose 30-100 mg/kg). Displays negligible cytotoxicity at pharmacological doses.
Form
Light yellow solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
849727-81-7
Chemical formula
C₂₂H₂₁FO₄
Structure formula
Purity
≥95% by HPLC
Solubility
DMSO (10 mg/ml)
Storage
Protect from light +2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.