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484100 5-Nitro-2-(3-phenylpropylamino)benzoic Acid - CAS 107254-86-4 - Calbiochem

Potent Cl⁻ channel blocker (IC₅₀ = 100 nM-100 µM), depending on channel subtype and assay method.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NPPB, ANO Blocker II, Anoctamin Blocker II, CaCC Blocker II, Calcium-Activated, TMEM16 Blocker II

Primary Target: Cl⁻ channel blocker
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484100
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
107254-86-4C₁₆H₁₆N₂O₄

Pricing & Availability

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484100-10MG
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      		 Plastic ampoule 10 mg
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      Description
      OverviewPotent Cl– channel blocker (IC50 = 100 nM-100 µM), depending on channel subtype and assay method. Inhibits cyclooxygenase (IC50 = 8 µM).
      Catalogue Number484100
      Brand Family Calbiochem®
      SynonymsNPPB, ANO Blocker II, Anoctamin Blocker II, CaCC Blocker II, Calcium-Activated, TMEM16 Blocker II
      References
      ReferencesIllek, B., et al. 1992. Am. J. Physiol. 263, C644.
      Kirk, K., et al. 1992. J. Biol. Chem. 267, 23475.
      Breuer, W., et al. 1989. Biochem. Biophys. Res. Commun. 163, 398.
      Wangermann, P., et al. 1986. Pflugers Arch. 407, S128.
      Product Information
      CAS number107254-86-4
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₆H₁₆N₂O₄
      Chemical formulaC₁₆H₁₆N₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCl⁻ channel blocker
      Primary Target IC<sub>50</sub>100 nM-100 µM as Cl-channel blocker
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      484100-10MG 04055977200676

      Documentation

      5-Nitro-2-(3-phenylpropylamino)benzoic Acid - CAS 107254-86-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      5-Nitro-2-(3-phenylpropylamino)benzoic Acid - CAS 107254-86-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      484100

      References

      Reference overview
      Illek, B., et al. 1992. Am. J. Physiol. 263, C644.
      Kirk, K., et al. 1992. J. Biol. Chem. 267, 23475.
      Breuer, W., et al. 1989. Biochem. Biophys. Res. Commun. 163, 398.
      Wangermann, P., et al. 1986. Pflugers Arch. 407, S128.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-April-2015 JSW
      SynonymsNPPB, ANO Blocker II, Anoctamin Blocker II, CaCC Blocker II, Calcium-Activated, TMEM16 Blocker II
      DescriptionPotent Cl- channel blocker (IC50 = 100 nM-100 µM), depending on channel subtype and assay method. Inhibits cyclooxygenase (IC50 = 8 µM).
      FormYellow solid
      CAS number107254-86-4
      Chemical formulaC₁₆H₁₆N₂O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml) or warm Ethanol
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesIllek, B., et al. 1992. Am. J. Physiol. 263, C644.
      Kirk, K., et al. 1992. J. Biol. Chem. 267, 23475.
      Breuer, W., et al. 1989. Biochem. Biophys. Res. Commun. 163, 398.
      Wangermann, P., et al. 1986. Pflugers Arch. 407, S128.