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100065 2-APB - CAS 524-95-8 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
524-95-8C₁₄H₁₆BNO

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100065-100MG
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      Description
      OverviewA cell-permeable modulator of Ins(1,4,5)P3-induced Ca2+ release. Inhibits Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations (IC50 = 42 µM) without affecting [3H]-Ins(1,4,5)P3 binding to its receptor. Does not affect Ca2+ release from the ryanodine-sensitive Ca2+ store in rat leg skeletal muscle and heart. Inhibits spontaneous as well as the phasic contractions induced by uterotonic agents. Also reported to inhibit angiotensin II-induced contractions in aortic muscles.
      Catalogue Number100065
      Brand Family Calbiochem®
      Synonyms2-Aminoethoxydiphenylborate, (2-Aminoethoxy)diphenylborane
      References
      ReferencesBrooke, R. T., et al. 2004. Lab. Invest. 84, 29.
      Gregory, R.B., et al. 2001. Biochem. J. 354, 285.
      Ma, H.T., et al. 2001. J. Biol. Chem. 276, 18888.
      Ascher-Landsberg, S., et al. 1999. Biochem. Biophys. Res. Commun. 264, 979.
      Maruyama, T., et al. 1997. J. Biochem. 122, 498.
      Product Information
      CAS number524-95-8
      ATP CompetitiveN
      FormWhite crystalline solid
      Hill FormulaC₁₄H₁₆BNO
      Chemical formulaC₁₄H₁₆BNO
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetIns(1,4,5)P3-induced Ca2+ release
      Primary Target IC<sub>50</sub>42 µM against Ins(1,4,5)P3-induced Ca2+ release from rat cerebellar microsomal preparations
      Purity≥97% by titration
      Physicochemical Information
      Cell permeableY
      Safety Information according to GHS
      RTECSED6150000
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      100065-100MG 07790788056766