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565755 γ-Secretase Inhibitor II - Calbiochem

The γ-Secretase Inhibitor II controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

γ-Secretase Inhibitor II - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MW167

Primary Target: γ-secretase
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565755
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₃₃H₅₇F₂N₅O₉

Pricing & Availability

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565755-1MG
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      		 Plastic ampoule 1 mg
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      Description
      OverviewA cell-permeable, reversible and selective peptidomimetic inhibitor of γ-secretase (IC50 = 13 µM for Aβ). Displays only weak inhibitory activity against calpain II (IC50 = 100 µM in a purified enzyme assay).

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number565755
      Brand Family Calbiochem®
      SynonymsMW167
      References
      ReferencesWolfe, M.S., et al. 1999. Biochemistry 38, 4720.
      Wolfe, M.S., et al. 1998. J. Med. Chem. 41, 6.
      Citron, M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13170.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₃₃H₅₇F₂N₅O₉
      Chemical formulaC₃₃H₅₇F₂N₅O₉
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetγ-secretase
      Primary Target IC<sub>50</sub>13 µM against γ-secretase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      565755-1MG 04055977267693

      Documentation

      γ-Secretase Inhibitor II - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      γ-Secretase Inhibitor II - Calbiochem Certificates of Analysis

      TitleLot Number
      565755

      References

      Reference overview
      Wolfe, M.S., et al. 1999. Biochemistry 38, 4720.
      Wolfe, M.S., et al. 1998. J. Med. Chem. 41, 6.
      Citron, M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13170.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-November-2014 JSW
      SynonymsMW167
      DescriptionA cell-permeable, reversible and selective peptidomimetic inhibitor of γ-secretase with an IC50 of 13 µM for the inhibition of amyloid β-protein (Aβ) production in β-amyloid precursor protein (APP)-transfected Chinese hamster ovary cells. Displays only weak inhibitory activity against calpain II (IC50 = 100 µM in a purified enzyme assay).
      FormWhite solid
      Chemical formulaC₃₃H₅₇F₂N₅O₉
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mM)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesWolfe, M.S., et al. 1999. Biochemistry 38, 4720.
      Wolfe, M.S., et al. 1998. J. Med. Chem. 41, 6.
      Citron, M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13170.