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14-865 p53-GST (recombinant protein)

p53-GST (recombinant protein): SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Key Applications: Enzyme Assays UniProt Number: P04637 Entrez Gene Number: NP_000537
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14-865
50 µg  
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      Description
      Catalogue Number14-865
      Brand Family Upstate
      Trade Name
      • Upstate
      Descriptionp53-GST (recombinant protein)
      OverviewN-terminal GST-tagged, recombinant full length human P53 protein, expressed in E. coli. Purified using glutathione agarose chromatography.
      Alternate Names
      • transformation related protein 53
      References
      Product Information
      PresentationRecombinant protein in buffer containing 20 mM Tris-HCl, pH 8.0, 100 mM KCl, 5mM glutathione, 0.5 mM EDTA, 0.5 mM DTT, 1 mM PMSF containing 20% glycerol.
      Quality LevelMQ100
      Applications
      Key Applications
      • Enzyme Assays
      Biological Information
      Concentration0.5 mg/mL
      Purity~95% by SDS-PAGE
      SourceFull-length human p53 protein, expressed in e. coli.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq]
      Gene Symbol
      • p53
      • TP53
      • tumor protein p53
      • TRP53
      • FLJ92943
      • LFS1
      Purification MethodGlutathione agarose chromatography
      UniProt Number
      Molecular Weight72 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by SDS-PAGE and Coomassie Stain
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at -20°C
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      14-865 04053252516108

      Documentation

      p53-GST (recombinant protein) SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      p53-GST (recombinant protein) Analysenzertifikate

      TitelChargennummer
      p53-GST (recombinant protein expressed in E. coli) - 2394263 2394263
      p53-GST (recombinant protein expressed in E. coli) 3042489
      p53-GST (recombinant protein expressed in E. coli) - 2197248 2197248
      p53-GST (recombinant protein expressed in E. coli) - 2273844 2273844
      p53-GST (recombinant protein expressed in E. coli) - 2300093 2300093
      p53-GST (recombinant protein expressed in E. coli) - 3282314 3282314
      p53-GST (recombinant protein expressed in E. coli) - 3437416 3437416
      p53-GST (recombinant protein expressed in E. coli) - 3447475 3447475
      p53-GST - 1953008 1953008
      p53-GST - 2049259 2049259
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