Millipore Sigma Vibrant Logo

681673 Wnt Antagonist III, Box5 - Calbiochem

Wnt Antagonist III, Box5, is a Wnt-5a-derived hexapeptide that antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration and invasion.

Wnt Antagonist III, Box5 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: Wnt-5a Antagonist, Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist

View Products on Sigmaaldrich.com
681673
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

Empirical Formula
C₃₀H₅₀N₆O₁₃S₂

Preis & Verfügbarkeit

Bestellnummer VerfügbarkeitVerpackung St./Pkg. Preis Menge
681673-10MG
Verfügbarkeit wird abgerufen...
—
Eingeschränkte Verfügbarkeit Eingeschränkte Verfügbarkeit
Lieferbar 
Produkt wurde eingestellt
Begrenzter Lagerbestand
Bestätigung der Verfügbarkeit erforderlich
    Restmenge: Angebot folgt
      Restmenge: Angebot folgt
      Bitte erfragen
      Kontakt zum Kundenservice
      Contact Customer Service

      		 Glasflasche 10 mg
      Preis wird abgerufen...
      Preis nicht abrufbar
      Die Mindestmenge muss ein Vielfaches sein von
      Maximum Quantity is
      Bei Bestätigung Weitere Informationen
      Sie haben () gespart
       
      —
      Bitte erfragen
      		 —
      Description
      OverviewA Wnt-5a-derived, N-terminally butyloxycarbonyl- (Boc) protected, hexa-peptide that effectively antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration, invasion, calcium response, and MARCKS phosphorylation. Replacing the N-terminal Boc with a formyl modification results in a peptide termed Foxy5 that mimics, instead of antagonizes, Wnt-5a biological activity in a Frizzled-5- (Fzd-5/Frz-5) dependent manner. The peptide sequence is conserved in multiple species, including human, mouse, and rat, and Box5 is expected to exert its effect via direct FZD5 binding as is the case with Foxy5.
      Catalogue Number681673
      Brand Family Calbiochem®
      SynonymsWnt-5a Antagonist, Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist
      References
      ReferencesJenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 19473.
      Safholm, A., et al. 2006. J. Biol. Chem. 281, 2740.
      Product Information
      FormWhite lyophilized solid
      Hill FormulaC₃₀H₅₀N₆O₁₃S₂
      Chemical formulaC₃₀H₅₀N₆O₁₃S₂
      Quality LevelMQ100
      Applications
      ApplicationWnt Antagonist III, Box5, is a Wnt-5a-derived hexapeptide that antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration and invasion.
      Biological Information
      Purity≥90% by HPLC
      Physicochemical Information
      Peptide Sequencet-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO₂H
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      681673-10MG 04055977225211

      Documentation

      Wnt Antagonist III, Box5 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Wnt Antagonist III, Box5 - Calbiochem Analysenzertifikate

      TitelChargennummer
      681673

      Literatur

      Übersicht
      Jenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 19473.
      Safholm, A., et al. 2006. J. Biol. Chem. 281, 2740.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-December-2010 RFH
      SynonymsWnt-5a Antagonist, Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist
      DescriptionA Wnt-5a-derived, N-terminally butyloxycarbonyl- (Boc) protected, hexa-peptide that effectively antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration, invasion, calcium response, and MARCKS phosphorylation. Replacing the N-terminal Boc with a formyl modification results in a peptide termed Foxy5 that mimics, instead of antagonizes, Wnt-5a biological activity in a Frizzled-5- (Fzd-5/Frz-5) dependent manner. The peptide sequence is conserved in multiple species, including human, mouse, and rat, and Box5 is expected to exert its effect via direct FZD5 binding as is the case with Foxy5.
      FormWhite lyophilized solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₀H₅₀N₆O₁₃S₂
      Peptide Sequencet-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO₂H
      Purity≥90% by HPLC
      SolubilityDMSO (50 mg/ml) or H₂O (4 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesJenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 19473.
      Safholm, A., et al. 2006. J. Biol. Chem. 281, 2740.