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532628 Vps34 Inhibitor, VPS34-IN1 - CAS 1383716-33-3 - Calbiochem

A cell-permeable, highly potent, selective, and reversible inhibitor of Vps34 activity (IC₅₀ = 25 nM).

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 1-(2-(2-Chloropyridin-4-ylamino)-4ʹ-(cyclopropylmethyl)-4,5ʹ-bipyrimidin-2ʹ-ylamino)-2-methylpropan-2-ol, Vacuolar Protein Sorting 34 Inhibitor, PIK3C3 Inhibitor

Primary Target: Vps34
532628
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
1383716-33-3C₂₁H₂₄ClN₇O

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      Description
      OverviewA cell-permeable pyridinylaminobipyrimidinylamino compound that acts as a highly potent, selective, and reversible inhibitor of Vps34 activity (IC50 = 25 nM using recombinant Vsp34:Vps15 complex). Displays excellent selectivity over 340 other protein kinases and 25 lipid kinases (even at ~ 1 µM), including class I and class II PI 3-kinases. Does not affect Ser473 or Thr308 phosphorylation status of Akt. Suppresses endosomal localization of GFP-2xFYVEHrs (IC50 = 100 nM) in U2OS cells. Rapidly inhibits SGK3 activity in a dose-dependent manner (~40% inhibition at 100 nM) and causes a diminution in T-loop and hydrophobic motif phosphorylation.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number532628
      Brand Family Calbiochem®
      Synonyms1-(2-(2-Chloropyridin-4-ylamino)-4ʹ-(cyclopropylmethyl)-4,5ʹ-bipyrimidin-2ʹ-ylamino)-2-methylpropan-2-ol, Vacuolar Protein Sorting 34 Inhibitor, PIK3C3 Inhibitor
      References
      ReferencesBago, R., et al. 2014. Biochem. J. 463, 413.
      Product Information
      CAS number1383716-33-3
      FormWhite powder
      Hill FormulaC₂₁H₂₄ClN₇O
      Chemical formulaC₂₁H₂₄ClN₇O
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetVps34
      Primary Target IC<sub>50</sub>25 nM using recombinant Vsp34:Vps15 complex
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5326280001 04055977281835

      Documentation

      Vps34 Inhibitor, VPS34-IN1 - CAS 1383716-33-3 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Bago, R., et al. 2014. Biochem. J. 463, 413.

      Technische Informationen

      Titel
      Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
      White Paper: Further considerations of antibody validation and usage.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-April-2015 JSW
      Synonyms1-(2-(2-Chloropyridin-4-ylamino)-4ʹ-(cyclopropylmethyl)-4,5ʹ-bipyrimidin-2ʹ-ylamino)-2-methylpropan-2-ol, Vacuolar Protein Sorting 34 Inhibitor, PIK3C3 Inhibitor
      DescriptionA cell-permeable pyridinylaminobipyrimidinylamino compound that acts as a highly potent, selective, and reversible inhibitor of Vps34 activity (IC50 = 25 nM using recombinant Vsp34:Vps15 complex). Displays excellent selectivity over 340 other protein kinases and 25 lipid kinases (even at ~ 1 µM), including class I and class II PI 3-kinases. Does not affect Ser473 or Thr308 phosphorylation status of Akt. Suppresses endosomal localization of GFP-2xFYVEHrs (IC50 = 100 nM) in U2OS cells. Rapidly inhibits SGK3 activity in a dose-dependent manner (~40% inhibition at 100 nM) and causes a diminution in T-loop and hydrophobic motif phosphorylation.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1383716-33-3
      Chemical formulaC₂₁H₂₄ClN₇O
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml). Use only fresh DMSO for reconstitution.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBago, R., et al. 2014. Biochem. J. 463, 413.