662086 Sigma-AldrichUCH-L1 Inhibitor - CAS 668467-91-2 - Calbiochem
The UCH-L1 Inhibitor, also referenced under CAS 668467-91-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
More>> The UCH-L1 Inhibitor, also referenced under CAS 668467-91-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: LDN-57444, Ubiquitin C-Terminal Hydrolase L1 Inhibitor, Ubiquitin C-Terminal Esterase L1 Inhibitor, Ubiquitin Thiolesterase L1 Inhibitor
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Übersicht
| Replacement Information |
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Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 668467-91-2 | C₁₇H₁₁Cl₃N₂O₃ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 662086-10MG |
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Glasflasche | 10 mg |
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| Description | |
|---|---|
| Overview | An isatin O-acyl oxime compound that acts as a potent, reversible, competitive, and active site-directed inhibitor of UCH-L1 (Ki = 0.40 µM; IC50 = 0.88 µM) with ~28-fold greater selectivity over UCH-L3 (Cat. No. 662090). Shown to increase proliferation of UCH-L1 expresssing tumor cell line SH-SY5Y at 5 µM. A useful tool for studying the roles of UCH-L1 in cancer, Parkinson’s disease, and other neurological disorders. Permeability may vary from cell type to cell type. |
| Catalogue Number | 662086 |
| Brand Family | Calbiochem® |
| Synonyms | LDN-57444, Ubiquitin C-Terminal Hydrolase L1 Inhibitor, Ubiquitin C-Terminal Esterase L1 Inhibitor, Ubiquitin Thiolesterase L1 Inhibitor |
| References | |
|---|---|
| References | Liu, Y., et al. 2003. Chem. Biol. 10, 837. |
| Product Information | |
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| CAS number | 668467-91-2 |
| ATP Competitive | Y |
| Form | Orange solid |
| Hill Formula | C₁₇H₁₁Cl₃N₂O₃ |
| Chemical formula | C₁₇H₁₁Cl₃N₂O₃ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | UCH-L1 |
| Primary Target IC<sub>50</sub> | 0.88 µM |
| Primary Target K<sub>i</sub> | 0.40 µM |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | N |
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| Toxicological Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 662086-10MG | 04055977261134 |
Documentation
UCH-L1 Inhibitor - CAS 668467-91-2 - Calbiochem SDB
| Titel |
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UCH-L1 Inhibitor - CAS 668467-91-2 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
|---|---|
| 662086 |
Literatur
| Übersicht |
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| Liu, Y., et al. 2003. Chem. Biol. 10, 837. |