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654256 TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem

The TNF-α Inhibitor, also referenced under CAS 1049741-03-8, controls the biological activity of TNF-α.

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Synonyme: TNF-α Inhibitor, Tumor Necrosis Factor-α Inhibitor, 6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl

Primary Target: TNF-α
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654256
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
1049741-03-8C₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O

Preis & Verfügbarkeit

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654256-5MG
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      Description
      OverviewA cell-permeable indolyl-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 µM). Shown to selectively inhibit TNF-α-, but not IL-1β-induced IκB-α degradation in HeLa cells (IC50 = 4.6 µM).
      Catalogue Number654256
      Brand Family Calbiochem®
      SynonymsTNF-α Inhibitor, Tumor Necrosis Factor-α Inhibitor, 6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl
      References
      ReferencesHe, M.M., et al. 2005. Science 310, 1022.
      Product Information
      CAS number1049741-03-8
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O
      Chemical formulaC₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTNF-α
      Primary Target IC<sub>50</sub>22 µM for non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      654256-5MG 04055977184631

      Documentation

      TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem Analysenzertifikate

      TitelChargennummer
      654256

      Literatur

      Übersicht
      He, M.M., et al. 2005. Science 310, 1022.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      SynonymsTNF-α Inhibitor, Tumor Necrosis Factor-α Inhibitor, 6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl
      DescriptionA cell-permeable indolyl-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 µM). Shown to selectively inhibit TNF-α-, but not IL-1β-induced IκB-α degradation in HeLa cells (IC50 = 4.6 µM).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1049741-03-8
      Chemical formulaC₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHe, M.M., et al. 2005. Science 310, 1022.