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505896 Sumanirole Maleate - CAS 179386-44-8 - Calbiochem

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: PNU 95666, PNU95666, Dopamine D₂ receptor Agonist, Sumanirole

Primary Target: D₂
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505896
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Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
179386-44-8C₁₁H₁₃N₃O•C₄H₄O₄

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      Description
      OverviewAn extremely selective dopamine D2 receptor agonist (Ki = 9 nM). Commonly used in Parkinson′s Disease models and to reproduce cocaine′s discriminative stimulus effects. Sumanirole has greater than 200-fold selectivity for the D2 receptor subtype versus the other dopamine receptor subtypes in radioligand binding assays. In cell-based assays, sumanirole is a fully efficacious agonist, with EC50 values between 17 and 75 nM. In animals, sumanirole elicits many physiological responses attributed to D2-like receptor function.
      Catalogue Number505896
      Brand Family Calbiochem®
      SynonymsPNU 95666, PNU95666, Dopamine D₂ receptor Agonist, Sumanirole
      References
      ReferencesAchat-Mendes, C. et al., 2010. J. Pharmacol. Exp. Ther. 334, 556.
      McCall, R. B. et al., 2005. J. Pharmacol. Exp. Ther. 314, 1248.
      Product Information
      CAS number179386-44-8
      FormOff-white solid
      Hill FormulaC₁₁H₁₃N₃O•C₄H₄O₄
      Chemical formulaC₁₁H₁₃N₃O•C₄H₄O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetD₂
      Primary Target K<sub>i</sub>9nM
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5058960001 04055977262506

      Documentation

      Sumanirole Maleate - CAS 179386-44-8 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Achat-Mendes, C. et al., 2010. J. Pharmacol. Exp. Ther. 334, 556.
      McCall, R. B. et al., 2005. J. Pharmacol. Exp. Ther. 314, 1248.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-November-2013 JSW
      SynonymsPNU 95666, PNU95666, Dopamine D₂ receptor Agonist, Sumanirole
      DescriptionAn extremely selective dopamine D2 receptor agonist (Ki = 9 nM). Commonly used in Parkinson′s Disease models and to reproduce cocaine′s discriminative stimulus effects. Sumanirole has greater than 200-fold selectivity for the D2 receptor subtype versus the other dopamine receptor subtypes in radioligand binding assays. In cell-based assays, sumanirole is a fully efficacious agonist, with EC50 values between 17 and 75 nM. In animals, sumanirole elicits many physiological responses attributed to D2-like receptor function.
      FormOff-white solid
      CAS number179386-44-8
      Chemical formulaC₁₁H₁₃N₃O•C₄H₄O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (16 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesAchat-Mendes, C. et al., 2010. J. Pharmacol. Exp. Ther. 334, 556.
      McCall, R. B. et al., 2005. J. Pharmacol. Exp. Ther. 314, 1248.