566660 Sigma-AldrichSmoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem
A cell-permeable Smoothened Agonist, SAG, CAS 364590-63-6, modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM).
More>> A cell-permeable Smoothened Agonist, SAG, CAS 364590-63-6, modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: N-Methyl-Nʹ-(3-pyridinylbenzyl)-Nʹ-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, SAG1.3
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
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| 364590-63-6 | C₂₈H₂₈ClN₃OS • 2HCl • 2H₂O |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 566660-1MG |
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Glasflasche | 1 mg |
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| 566660-5MG |
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Glasflasche | 5 mg |
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| Description | |
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| Overview | A cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Smo internalization. Shown to induce Hedgehog pathway activation (EC50 = ∼ 3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations. A 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566661) in H2O is also available. |
| Catalogue Number | 566660 |
| Brand Family | Calbiochem® |
| Synonyms | N-Methyl-Nʹ-(3-pyridinylbenzyl)-Nʹ-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, SAG1.3 |
| Product Information | |
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| CAS number | 364590-63-6 |
| Form | Light yellow solid |
| Hill Formula | C₂₈H₂₈ClN₃OS • 2HCl • 2H₂O |
| Chemical formula | C₂₈H₂₈ClN₃OS • 2HCl • 2H₂O |
| Hygroscopic | Hygroscopic |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥98% by HPLC |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 566660-1MG | 07790788051570 |
| 566660-5MG | 04055977191578 |
Documentation
Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem SDB
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Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 566660 |
Literatur
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| Wang, J., et al. 2010. Proc. Natl. Acad. Sci. USA. 107, 9323. Meloni, A.R., et al. 2006. Mol. Cell. Biol. 26, 7750. Chen, W., et al. 2004. Science 306, 2257. Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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