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554325 Resveratrol - CAS 501-36-0 - Calbiochem

Übersicht

Key Spec Table

CAS #Empirical Formula
501-36-0C₁₄H₁₂O₃

Preis & Verfügbarkeit

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554325-25MG
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      Kst.-Ampulle 25 mg
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      Description
      OverviewA phenolic product found in both grape skins and wines. Has antifungal, antitumor, and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED50 = 15 µM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED50 = 3.7 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED50 = 27 µM) and acts as an anti-mutagenic agent (ED50 = 15 µM) in TM677 cells treated with DMBA. Also a selective inhibitor of P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells.
      Catalogue Number554325
      Brand Family Calbiochem®
      Synonymstrans-3,4ʹ,5-Trihydroxystilbene
      References
      ReferencesHowitz, K.T., et al. 2003. Nature 425, 191.
      Lin, H.Y., et al. 2002. J. Urol. 168, 748.
      Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
      Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun. 262, 20.
      Jang, M., et al. 1997. Science 275, 218.
      Chen, C.K., et al. 1996. Gen. Pharmacol. 27, 363.
      Product Information
      CAS number501-36-0
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₄H₁₂O₃
      Chemical formulaC₁₄H₁₂O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetCOX-1
      Primary Target IC<sub>50</sub>ED50 = 15 µM against COX-1
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Bestellnummer GTIN
      554325-25MG 04055977193053