553210 Sigma-AldrichRapamycin - CAS 53123-88-9 - Calbiochem
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Synonyme: mTOR Inhibitor I
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Übersicht
| Replacement Information |
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Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 53123-88-9 | C₅₁H₇₉NO₁₃ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 553210-100UG |
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Kst.-Ampulle | 100 μg |
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| 553210-10MG |
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Glasflasche | 10 mg |
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| 553210-1MG |
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Kst.-Ampulle | 1 mg |
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| 553210-5MG |
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Glasflasche | 5 mg |
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| Description | |
|---|---|
| Overview | Anti-fungal and immunosuppressant. Selectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser473 appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase. A 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553211) in DMSO and a 10 mM (1 mg/109 µl) solution of Rapamycin (Cat. No. 553212) in EtOH is also available. |
| Catalogue Number | 553210 |
| Brand Family | Calbiochem® |
| Synonyms | mTOR Inhibitor I |
| Product Information | |
|---|---|
| CAS number | 53123-88-9 |
| ATP Competitive | N |
| Form | Clear film |
| Hill Formula | C₅₁H₇₉NO₁₃ |
| Chemical formula | C₅₁H₇₉NO₁₃ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ200 |
| Applications |
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| Biological Information | |
|---|---|
| Primary Target | Mammalian target of rapamycin (mTOR) |
| Primary Target IC<sub>50</sub> | 50 pM against p70 S6 kinase |
| Purity | ≥99% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | N |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS | |
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| RTECS | VE6250000 |
| Safety Information |
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| Product Usage Statements |
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| Packaging Information |
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| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 553210-100UG | 04055977193510 |
| 553210-10MG | 07790788060305 |
| 553210-1MG | 04055977193480 |
| 553210-5MG | 04055977193534 |
Documentation
Rapamycin - CAS 53123-88-9 - Calbiochem SDB
| Titel |
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Rapamycin - CAS 53123-88-9 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 553210 |
Literatur
| Übersicht |
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| Chen, T., et al. 2011. Aging Cell. 10, 908. Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794. Braun, W., et al. 1995. FASEB J. 9, 63. Nielsen, F.C., et al. 1995. Nature 377, 358. Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493. Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350. Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734. Terada, N., et al. 1993. J. Biol. Chem. 268, 12062. Kuo, J., et al. 1992. Nature 358, 70. Price, D.J., et al. 1992. Science 257, 973. Heitman, J., et al. 1991. Science 253, 905. Kay, J.E., et al. 1991. Immunology 72, 544. Schreiber, S.L. 1991. Science 251, 283. Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231. Dumont, F.J., et al. 1990. J. Immunol. 144, 251. |
Broschüre
| Titel |
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| Bulk Product Guide |
| Caspases and other Apoptosis Related Tools Brochure |
Datenblatt
| Titel |
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| Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation |
Posters
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| Human Kinome & InhibitorSelect™ Libraries |
Literaturstellen
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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