529573 Sigma-AldrichPP2 - CAS 172889-27-9 - Calbiochem
PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC₅₀ = 4, 5, 5, &100 nM for p56lck, p59fynT, Hck, & Src, respectively).
More>> PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC₅₀ = 4, 5, 5, &100 nM for p56lck, p59fynT, Hck, & Src, respectively). Less<<Synonyme: AG 1879, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine
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Übersicht
Key Spec Table
CAS # | Empirical Formula |
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172889-27-9 | C₁₅H₁₆ClN₅ |
Preis & Verfügbarkeit
Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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529573-1MG |
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Kst.-Ampulle | 1 mg |
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529573-5MG |
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Glasflasche | 5 mg |
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Description | |
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Overview | A potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. Inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), Hck (IC50 = 5 nM), and Src (IC50 = 100 nM). Does not significantly affect the activity of EGFR kinase (IC50 = 480 nM), JAK2 (IC50 > 50 µM), or ZAP-70 (IC50 >100 µM). Inhibits the activation of focal adhesion kinase and its phosphorylation at Tyr577. Also potently inhibits anti-CD3-stimulated tyrosine phosphorylation of human T cells (IC50 = 600 nM). A 10 mM (1 mg/331 µl) solution of PP2 (Cat. No. 529576) in DMSO also available. |
Catalogue Number | 529573 |
Brand Family | Calbiochem® |
Synonyms | AG 1879, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine |
References | |
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References | Karni, R., et al. 2003. FEBS Lett. 537, 47. Salazar, E.P., and Rozengurt, E. 1999. J. Biol. Chem. 274, 28371. Hanke, J.H., et al. 1996. J. Biol. Chem. 271, 695. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76. |
Product Information | |
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CAS number | 172889-27-9 |
ATP Competitive | Y |
Form | Off-white solid |
Hill Formula | C₁₅H₁₆ClN₅ |
Chemical formula | C₁₅H₁₆ClN₅ |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Physicochemical Information | |
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Cell permeable | N |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Bestellnummer | GTIN |
529573-1MG | 07790788051198 |
529573-5MG | 04055977269802 |