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14-483M PKCγ Protein, active, 250 µg

Active, recombinant, full-length human PKCγ, containing N-terminal His6 tag. For use in Kinase Assays.

PKCγ Protein, active, 250 µg: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
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14-483M
250 µg  Also available in 10 μg size (cat#14-483) and in bulk (cat# 14-483-K).
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      Übersicht

      Replacement Information
      Description
      Catalogue Number14-483M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPKCγ Protein, active, 250 µg
      OverviewRecombinant, full-length human PKCγ, containing N-terminal His6 tag

      PKC Lipid activator (Catalog # 20-133) is required for use.
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, recombinant, full-length human PKCγ, containing N-terminal His6 tag. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceHuman PKCγ expressed by baculovirus in Sf21 cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryProtein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).
      Gene Symbol
      • PRKCG
      • SCA14
      • MGC57564
      • PKC-gamma
      • PKCG
      • PKCC
      Protein TargetPKCγ
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyAGC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P05129 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
      COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domain (By similarity).
      SIZE: 697 amino acids; 78448 Da
      SUBUNIT: Interacts with CDCP1.
      DISEASE: SwissProt: P05129 # Defects in PRKCG are the cause of spinocerebellar ataxia 14 (SCA14) [MIM:605361]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of autosomal dominant cerebellar ataxias (ADCA). Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements. Spinocerebellar ataxia is caused by degeneration of the cerebellum with variable involvement of the brainstem and spinal cord.
      SIMILARITY: SwissProt: P05129 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 2 phorbol-ester/DAG-type zinc fingers. & Contains 1 protein kinase domain.
      Molecular Weight79.5kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of Histone H1
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-483) and in bulk (cat# 14-483-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      14-483M 04053252625701

      Verwandte Produkte & Anwendungen

      Alternative Packsize

      Bestellnummer Beschreibung  
      14-483 PKCγ Protein, active, 10 µg Preis & Verfügbarkeit

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      Kategorien

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases