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12-151 PKA Inhibitor peptide

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12-151
2 mg  
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      Description
      Catalogue Number12-151
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPKA Inhibitor peptide
      Product Information
      PresentationLyophilized powder (from H2O)
      Quality LevelMQ100
      Applications
      ApplicationThe PKA Inhibitor peptide controls the biological activity of PKA. This small molecule/inhibitor is primarily used for Neuroscience applications.
      Key Applications
      • Kinase Assay
      Biological Information
      Entrez Gene Number
      Entrez Gene SummarycAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
      Gene Symbol
      • PRKACA
      • MGC102831
      • MGC48865
      • PKACA
      Protein TargetPKA
      Target Sub-FamilyAGC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P17612 # Phosphorylates a large number of substrates in the cytoplasm and the nucleus.
      SIZE: 351 amino acids; 40590 Da
      SUBUNIT: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity).
      TISSUE SPECIFICITY: Isoform 2 is sperm specific.
      PTM: Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively (By similarity).
      SIMILARITY: SwissProt: P17612 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by inhibition of PKA catalytic subunit (14-114).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsLyophilized: Stable for 2 years at -20°C . Rehydrated: Stable for 1 year at -20°C.
      Packaging Information
      Material Size2 mg
      Global Trade Item Number
      Bestellnummer GTIN
      12-151 04053252333507