474790 Sigma-AldrichMG-132 - CAS 133407-82-6 - Calbiochem
A cell-permeable, potent, reversible proteasome inhibitor (Ki = 4 nM).
More>> A cell-permeable, potent, reversible proteasome inhibitor (Ki = 4 nM). Less<<MG-132 - CAS 133407-82-6 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Z-LLL-CHO, Proteasome Inhibitor XI
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 133407-82-6 | C₂₆H₄₁N₃O₅ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 474790-10MG |
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Kst.-Ampulle | 10 mg |
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| 474790-1MG |
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Kst.-Ampulle | 1 mg |
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| 474790-20MG |
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20 mg |
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| 474790-5MG |
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Kst.-Ampulle | 5 mg |
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| Description | |
|---|---|
| Overview | A potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). Also reported to increases the survival rate of mesenchymal stem cells following their transplantation. Prevents β-secretase cleavage. A 10 mM (1 mg/210 µl) solution of MG-132 (Cat. No. 474791) in DMSO is also available. This material is ≥98% pure by HPLC. A material with ≥95% purity by HPLC (Cat. No. 474787) is also available. |
| Catalogue Number | 474790 |
| Brand Family | Calbiochem® |
| Synonyms | Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Z-LLL-CHO, Proteasome Inhibitor XI |
| Product Information | |
|---|---|
| CAS number | 133407-82-6 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₂₆H₄₁N₃O₅ |
| Chemical formula | C₂₆H₄₁N₃O₅ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | proteasome |
| Primary Target IC<sub>50</sub> | 3 µM against NF-κB activation |
| Primary Target K<sub>i</sub> | 4 nM against proteasome |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Peptide Sequence | Z-Leu-Leu-Leu-CHO |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 474790-10MG | 04055977185485 |
| 474790-1MG | 07790788050436 |
| 474790-20MG | 04055977185492 |
| 474790-5MG | 07790788050443 |
Documentation
MG-132 - CAS 133407-82-6 - Calbiochem SDB
| Titel |
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MG-132 - CAS 133407-82-6 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 474790 |
Literatur
| Übersicht |
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| Li, Z.W. et al. 2011. Sheng Li Xue Bao. 63, 525. Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476. Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373. Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279. Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865. Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280. Wiertz, E.J., et al. 1996. Cell 84, 769. Jensen, T.J., et al. 1995. Cell 83, 129. Read, M.A., et al. 1995. Immunity 2, 493. Rock, K.L., et al. 1994. Cell 78, 761. |
Broschüre
| Titel |
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| Caspases and other Apoptosis Related Tools Brochure |
| Proteasomes Technical Bulletin |
Literaturstellen
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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