444966 Sigma-AldrichMEK1/2 Inhibitor III - CAS 391210-10-9 - Calbiochem
MEK1/2 Inhibitor III, CAS 391210-10-9, is a cell-permeable, non-competitive, highly potent MEK/MAPKK/MKK inhibitor that blocks cellular Erk1/2 phosphorylation (IC50 = 25 in serum starved HeLa cells).
More>> MEK1/2 Inhibitor III, CAS 391210-10-9, is a cell-permeable, non-competitive, highly potent MEK/MAPKK/MKK inhibitor that blocks cellular Erk1/2 phosphorylation (IC50 = 25 in serum starved HeLa cells). Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD 0325901, PD325901, PD0325901, MEK Inhibitor III
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
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| 391210-10-9 | C₁₆H₁₄F₃IN₂O₄ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 444966-5MG |
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Kst.-Ampulle | 5 mg |
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| Description | |
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| Overview | A cell-permeable benzamide compound that acts as a non-competitive, highly potent, selective MEK/MAPKK/MKK inhibitor and effectively blocks cellular Erk1/2 phosphorylation (by >90% in serum-starved HeLa after serum-stimulation and 50% in C26 with 25 and 0.33 nM inhibitor, respectively), while exhibiting little or no effect against the activity of Erk1/2 or a panel of 66 other kinases even at concentrations as high as 10 µM in cell-free kinase assays. Shown to be orally available in mice and suppress both the growth of and Erk phosphorylation in BRAF(V600E)-expressing SKMEL28 cell-derived tumor in vivo. Also available in InSolution™ format (Cat. No. 444968). |
| Catalogue Number | 444966 |
| Brand Family | Calbiochem® |
| Synonyms | N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD 0325901, PD325901, PD0325901, MEK Inhibitor III |
| Product Information | |
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| CAS number | 391210-10-9 |
| Form | White to off-white solid |
| Hill Formula | C₁₆H₁₄F₃IN₂O₄ |
| Chemical formula | C₁₆H₁₄F₃IN₂O₄ |
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| Quality Level | MQ100 |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 444966-5MG | 04055977204520 |
Documentation
MEK1/2 Inhibitor III - CAS 391210-10-9 - Calbiochem SDB
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MEK1/2 Inhibitor III - CAS 391210-10-9 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 444966 |
Literatur
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| Barrett, S.D., et al. 2008. Bioorg. Med. Chem. Lett. 18, 6501. Leyton, J., et al. 2008. Mol. Cancer Ther. 7, 3112. Silva, J., et al. 2008. PLoS Biol. 6, 2237. Ying, Q.L., et al. 2008. Nature 453, 519. Bain, J., et al. 2007. Biochem. J. 408, 297. Solit, D.B., et al. 2006. Nature 439, 358. |
Datenblatt
| Titel |
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| Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation |