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119114 Luciferase Inhibitor II - CAS 10205-56-8 - Calbiochem

The Luciferase Inhibitor II, also referenced under CAS 10205-56-8, controls the biological activity of Luciferase.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 4-(1,3-Benzothiazol-2-yl)-N,N-dimethylaniline

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119114
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
10205-56-8C₁₅H₁₄N₂S

Preis & Verfügbarkeit

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119114-5MG
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      Description
      OverviewA 2-arylbenzothiazole compound that acts as an inhibitor against the ATP-dependent Photinus pyralis (lucPpy) and Photuris pennsylvanica (lucPpe) luciferase activity (IC50 = 0.2 and 0.32 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme). Unlike Luciferase Inhibitor I (Cat. No. 119113), Luciferase Inhibitor II is competitive with respect to luciferin and exhibits reduced potency against lucPpe-based commercial luciferase-luciferin formulations with high luciferin concentration (IC50 = 10 µM against Promega's Kinase-Glo®; ineffective against Kinase-Glo® Plus and Kinase-Glo® Max; at a 3-fold formulation dilution and 6.77 µM ATP).
      Catalogue Number119114
      Brand Family Calbiochem®
      Synonyms4-(1,3-Benzothiazol-2-yl)-N,N-dimethylaniline
      References
      ReferencesAuld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
      Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.
      Product Information
      CAS number10205-56-8
      DeclarationMarketed by Promega Corp. under the registered trademarks.
      FormPale green solid
      Hill FormulaC₁₅H₁₄N₂S
      Chemical formulaC₁₅H₁₄N₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 22-26-36

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      119114-5MG 04055977223248

      Documentation

      Luciferase Inhibitor II - CAS 10205-56-8 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Luciferase Inhibitor II - CAS 10205-56-8 - Calbiochem Analysenzertifikate

      TitelChargennummer
      119114

      Literatur

      Übersicht
      Auld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
      Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2011 RFH
      Synonyms4-(1,3-Benzothiazol-2-yl)-N,N-dimethylaniline
      DescriptionA 2-arylbenzothiazole compound that acts as an inhibitor against the ATP-dependent Photinus pyralis (lucPpy) and Photuris pennsylvanica (lucPpe) luciferase activity (IC50 = 0.2 and 0.32 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme). Unlike Luciferase Inhibitor I (Cat. No. 119113), Luciferase Inhibitor II is competitive with respect to luciferin and exhibits reduced potency against lucPpe-based commercial luciferase-luciferin formulations with high luciferin concentration (IC50 = 10 µM against Promega's Kinase-Glo®; ineffective against Kinase-Glo® Plus and Kinase-Glo® Max; at a 3-fold formulation dilution and 6.77 µM ATP).
      FormPale green solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number10205-56-8
      Chemical formulaC₁₅H₁₄N₂S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (0.5 mg/ml) or Ethanol (3 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesAuld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
      Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.