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108975 Leupeptin, Hemisulfate, Microbial - CAS 103476-89-7 - Calbiochem

Leupeptin hemisulfate, CAS 103476-89-7, is a reversible inhibitor of trypsin-like proteases and cysteine proteases

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: Ac-LLR-CHO, ½H₂SO₄

Primary Target: trypsin- and cysteine-like proteases
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      103476-89-7C₂₀H₃₈N₆O₄ . 1/2H₂SO₄
      Description
      OverviewA reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune responses of HIV+ donors. Also available as a 50 mM solution in H2O (Cat. No. 509281).
      Catalogue Number108975
      Brand Family Calbiochem®
      SynonymsAc-LLR-CHO, ½H₂SO₄
      References
      ReferencesMontenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
      Sarin, A., et al. 1994. J. Immunol. 153, 862.
      Product Information
      CAS number103476-89-7
      ATP CompetitiveN
      FormWhite lyophilized solid
      Hill FormulaC₂₀H₃₈N₆O₄ . 1/2H₂SO₄
      Chemical formulaC₂₀H₃₈N₆O₄ . 1/2H₂SO₄
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Primary Targettrypsin- and cysteine-like proteases
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceAc-Leu-Leu-arginal, hemisulfate
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Aqueous stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      108975 0

      Documentation

      Leupeptin, Hemisulfate, Microbial - CAS 103476-89-7 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Leupeptin, Hemisulfate, Microbial - CAS 103476-89-7 - Calbiochem Analysenzertifikate

      TitelChargennummer
      108975

      Literatur

      Übersicht
      Montenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
      Sarin, A., et al. 1994. J. Immunol. 153, 862.

      Broschüre

      Titel
      Bulk Product Guide
      Caspases and other Apoptosis Related Tools Brochure

      Literaturstellen

      Titel
    • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
      		•
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-March-2010 JSW
      SynonymsAc-LLR-CHO, ½H₂SO₄
      DescriptionA reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune response in HIV+ donors. Often used for the inhibition of endoproteinase Lys-C, kallikrein, papain, plasmin, thrombin, cathepsin B, and trypsin. Leupeptin does not inhibit chymotrypsin, elastase, renin, or pepsin. The recommended working range is 10-100 µM for most applications.
      FormWhite lyophilized solid
      CAS number103476-89-7
      Chemical formulaC₂₀H₃₈N₆O₄ . 1/2H₂SO₄
      Peptide SequenceAc-Leu-Leu-arginal, hemisulfate
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityH₂O (50 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Aqueous stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 5456
      ReferencesMontenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
      Sarin, A., et al. 1994. J. Immunol. 153, 862.
      Citation
    • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
      		•