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373225 Sigma-AldrichHdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

SDB
Analysenzertifikat
Literatur
Data Sheet

Synonyme: N-((3,3,3-Trifluoro-2-trifluromethyl)propionyl)sulfanilamide, Mdm2 E3 Ligase Inhibitor, MDM2 Inhibitor V

Primary Target: ubiquitination of p53 in vitro

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Übersicht

Replacement Information

Key Spec Table

CAS #	Empirical Formula
414905-09-2	C₁₀H₈F₆N₂O₃S

Preis & Verfügbarkeit

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Description
Overview	This product has been discontinued. A cell-permeable and reversible inhibitor of Hdm2 E3 ligase that selectively blocks Hdm2 E3-mediated ubiquitination. Has been shown to inhibit ubiquitination of p53 in vitro (IC₅₀ = 12.7 µM using Ub-Ubc as the donor substrate). Exhibits little effect towards other ubiquitin-using enzymes (IC₅₀ > 100 µM for E1, Nedd-4, and SCF) or the auto-ubiquitination activity of Hdm2. The inhibition is non-competitive with respect to either the donor or acceptor substrate.
Catalogue Number	373225
Brand Family	Calbiochem®
Synonyms	N-((3,3,3-Trifluoro-2-trifluromethyl)propionyl)sulfanilamide, Mdm2 E3 Ligase Inhibitor, MDM2 Inhibitor V

References
References	Lai, Z., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14734.

Product Information
CAS number	414905-09-2
ATP Competitive	N
Form	Pale yellow solid
Hill Formula	C₁₀H₈F₆N₂O₃S
Chemical formula	C₁₀H₈F₆N₂O₃S
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	ubiquitination of p53 in vitro
Primary Target IC<sub>50</sub>	12.7 µM inhibiting ubiquitination of p53 in vitro using Ub-Ubc as the donor substrate
Purity	≥95% by NMR

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Bestellnummer	GTIN
373225-5MG	04055977190977

Documentation

Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem SDB

Titel
Sicherheitsdatenblatt (SDB)

Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem Analysenzertifikate

Titel	Chargennummer
373225	Chargen-Nr.

Literatur

Übersicht
Lai, Z., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14734.

Datenblatt

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	07-July-2014 JSW
Synonyms	N-((3,3,3-Trifluoro-2-trifluromethyl)propionyl)sulfanilamide, Mdm2 E3 Ligase Inhibitor, MDM2 Inhibitor V
Description	A cell-permeable and reversible inhibitor of Hdm2 E3 ligase that selectively blocks Hdm2 E3-mediated ubiquitination. Has been shown to inhibit ubiquitination of p53 in vitro (IC₅₀ = 12.7 µM using Ub-Ubc as the donor substrate). Exhibits little effect towards other ubiquitin-using enzymes (IC₅₀ >100 µM for E1, Nedd-4, and SCF) or the auto-ubiquitination activity of Hdm2. The inhibition is non-competitive with respect to either the donor or acceptor substrate.
Form	Pale yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	414905-09-2
Chemical formula	C₁₀H₈F₆N₂O₃S
Structure formula
Purity	≥95% by NMR
Solubility	DMSO (50 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Lai, Z., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14734.

Kategorien

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Proteasome and Ubiquitination Pathway Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > DNA Damage/Repair > MDM2 Inhibitors

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