GSK-3 Antibodies, Proteins, Inhibitors
Empfohlene Produkte
-
MABE1923-25UG Sigma-Aldrich Anti-T2A Antibody, clone 5E6 -
GF171 Sigma-Aldrich Endostatin Protein, Human Recombinant -
AB9774-50UL Sigma-Aldrich Anti-Somatostatin Receptor Type 3 Antibody -
8222901000 Sigma-Aldrich 2-Naphthol -
SGW3A47HH3 Millipore OptiScale-Kapsule mit 1,0/0,2-µm-Polysep II-Medium, 1/4"-Schlaucholive beidseitig -
12177 Millipore Agar - CAS 9002-18-0 - Calbiochem -
70856-3 Millipore RNase A Solution -
CVHI01TPE Millipore Durapore CVHI-Filterelement, 10", 0,45 µm, Adaptercode 0 -
8188230100 Sigma-Aldrich Natriumborhydrid
Überblick
Spezifikationen
Bestellinformationen
Documentation
Verwandte Produkte & Anwendungen
Kategorien
| Life Science Research > Antibodies and Assays > Primary Antibodies |
Glycogen synthase kinase-3 (GSK-3), a multifunctional serine/threonine kinase, is a key regulator of numerous signaling pathways. Two isoforms of GSK-3 are reported in mammals: a 51 kDa GSK-3a and a 47 kDa GSK-3b. These two isoforms exhibit about 98% homology in their kinase domains, but share only about 36% identity in the last 76 C-terminal amino acid residues. GSK-3a contains a glycine-rich extension at its N-terminus. A minor (~15% of total) splice variant of GSK-3b, GSK-3b2, has also been identified, which contains a 13-residue insert within the kinase domain. It exhibits reduced kinase activity towards tau protein compared with ‘unspliced’ GSK-3b. GSK-3b2 is localized primarily to neuronal cell bodies, unlike unspliced GSK-3b that is also found in neuronal processes. GSK-3b plays a key inhibitory role in the Wnt signaling pathway. Wnt genes encode a large family of secreted, cysteine-rich proteins that are important in development and in maintenance of adult tissues.
GSK-3, a key component in glycogen metabolism, has been heavily implicated in the incidence and progression of a number of diseases including diabetes, cancer and AD. Its most well-known function is constitutive phosphorylation of glycogen synthase. Conversely, GSK-3 inhibition prevents Tau hyperphosphorylation and serves as a protectant against neuronal apoptosis, as well as blocking the accumulation and toxicity of Ab/tau. Unlike most other kinases, GSK-3 is constitutively active, and its effects are regulated primarily through inhibition of its activity. Increased expression and activity of GSK-3 have been implicated both in Type II diabetes and AD, whereas, decreases in its constitutive cellular function are closely linked to various forms of cancer. The therapeutic potential of GSK-3 inhibitors has become a major area of pharmaceutical interest, and the development of GSK-3 targeted therapeutics hold excellent opportunities for the treatment of GSK-3-associated disease states.