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14-551M Fms Protein, active, 250 µg

Active, N-terminal His6-tagged, recombinant, human Fms, amino acids 538-end, for use in Kinase Assays.

Fms Protein, active, 250 µg: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
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14-551M
250 µg  Also available in 10 μg size (cat#14-551) and in bulk (cat# 14-551-K).
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      Übersicht

      Replacement Information
      Description
      Catalogue Number14-551M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionFms Protein, active, 250 µg
      OverviewN-terminal His6-tagged, recombinant, human Fms, amino acids 538-end
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, N-terminal His6-tagged, recombinant, human Fms, amino acids 538-end, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceHuman Fms expressed by baculovirus in Sf21 insect cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.
      Gene Symbol
      • CSF1R
      • FIM2
      • CSF-1-R
      • C-FMS
      • CSFR
      • c-fms
      • CD115
      • FMS
      Protein TargetFms
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P07333 # This protein is the receptor for CSF-1, it is a protein tyrosine-kinase transmembrane receptor.
      SIZE: 972 amino acids; 107984 Da
      SUBUNIT: Interacts with INPPL1/SHIP2 and THOC5 (By similarity).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Expressed in bone marrow and in differentiated blood mononuclear cells.
      SIMILARITY: SwissProt: P07333 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
      Molecular Weight50.2kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of IGF-R1tide
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-551) and in bulk (cat# 14-551-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      14-551M 04053252362095

      Verwandte Produkte & Anwendungen

      Alternative Packsize

      Bestellnummer Beschreibung  
      14-551 Fms Protein, active, 10 µg Preis & Verfügbarkeit

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      Kategorien

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases