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F1904 Fibronectin 120 kDa α Chymotryptic Fragment (Cell Attachment region), Human purified

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F1904
500 µg  
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      Übersicht

      Replacement Information

      Key Spec Table

      Key Applications
      CULT
      Description
      Catalogue NumberF1904
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionFibronectin 120 kDa α Chymotryptic Fragment (Cell Attachment region), Human purified
      OverviewPROPERTIES:

      Contains the cell attachment region of the fibronectin molecule.
      References
      Product Information
      HS Code3502 90 90
      PresentationPurified protein. Lyophilized in sodium citrate buffer, pH 7.4. Reconstitute with water.
      Quality LevelMQ100
      Applications
      Key Applications
      • Cell Culture
      Application NotesF1904 is suitable for use in ELISA and affinity chromatography, and possibly molecular mapping of fibronectin function.
      Biological Information
      Concentration1 mg/mL
      PurityOne major band at 120kDa in SDS-PAGE
      SourceHuman plasma cryoprecipitate (plasma fibronectin), assayed negative for hepatitis B virus, hepatitis C Virus (HCV), HIV-1, HIV-2, HTLV-1, HTLV-2 and Treponema pallidum. Handle as if potentially infectious.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined.
      Gene Symbol
      • FN1
      • DKFZp686O13149
      • DKFZp686H0342
      • DKFZp686I1370
      • MSF
      • FN
      • CIG
      • DKFZp686F10164
      • LETS
      • FINC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P02751 # Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth (By similarity).
      SIZE: 2386 amino acids; 262607 Da
      SUBUNIT: Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1.
      SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
      TISSUE SPECIFICITY: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.DEVELOPMENTAL STAGE: Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age.
      PTM: Sulfated.
      SIMILARITY: SwissProt: P02751 ## Contains 12 fibronectin type-I domains. & Contains 2 fibronectin type-II domains. & Contains 16 fibronectin type-III domains.
      Stem Cell Type
      • Human Embryonic Stem Cells
      • Mesenchymal Stem Cells
      • Neural Stem Cells
      • Hematopoietic Stem Cells
      • Epithelial Cells
      • Pancreatic Stem Cells
      • Induced Pluripotent Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain material at -20°C for 3 months or -70°C for six months.
      Packaging Information
      Material Size500 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      F1904 04053252279539

      Documentation

      Fibronectin 120 kDa α Chymotryptic Fragment (Cell Attachment region), Human purified SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Fibronectin 120 kDa α Chymotryptic Fragment (Cell Attachment region), Human purified Analysenzertifikate

      TitelChargennummer
      PURIFIED HUMAN FIBRONECTIN 2470386
      PURIFIED HUMAN FIBRONECTIN ALPHA-CHYMOTRYPTIC FRAGMENT 120K (cell attachment) - 2387763 2387763
      PURIFIED HUMAN FIBRONECTIN - 3821672 3821672
      PURIFIED HUMAN FIBRONECTIN -2595768 2595768
      PURIFIED HUMAN FIBRONECTIN -2605443 2605443
      PURIFIED HUMAN FIBRONECTIN -2668113 2668113
      PURIFIED HUMAN FIBRONECTIN -2736695 2736695
      PURIFIED HUMAN FIBRONECTIN ALPHA-CHYMOTRYPTIC FRAGMENT 120K (cell attachment) 2933271
      PURIFIED HUMAN FIBRONECTIN ALPHA-CHYMOTRYPTIC FRAGMENT 120K (cell attachment) 3135961
      PURIFIED HUMAN FIBRONECTIN ALPHA-CHYMOTRYPTIC FRAGMENT 120K (cell attachment) 2903951

      Literatur

      ÜbersichtPub Med ID
      Fibronectin: purification, immunochemical properties, and biological activities.
      Ruoslahti, E, et al.
      Meth. Enzymol., 82 Pt A: 803-31 (1982)  1981

      7078457 7078457
      Location of the cell-attachment site in fibronectin with monoclonal antibodies and proteolytic fragments of the molecule.
      Pierschbacher, M D, et al.
      Cell, 26: 259-67 (1981)  1981

      Abstract anzeigen
      6174240 6174240

      Datenblatt

      Titel
      PURIFIED HUMAN FIBRONECTIN ALPHA-CHYMOTRYPTIC FRAGMENT 120K

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      Kategorien

      Life Science Research > Proteins and Enzymes > ECM Proteins for Plate Coating