219478 Sigma-AldrichCdk4 Inhibitor III - CAS 265312-55-8 - Calbiochem
The Cdk4 Inhibitor III, also referenced under CAS 265312-55-8, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The Cdk4 Inhibitor III, also referenced under CAS 265312-55-8, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: 5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazole, Ryuvidine
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 265312-55-8 | C₁₅H₁₂N₂O₂S |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 219478-5MG |
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Kst.-Ampulle | 5 mg |
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| Description | |
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| Overview | A cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 µM for Cdk4/D1 and > 200 µM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 µg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120). |
| Catalogue Number | 219478 |
| Brand Family | Calbiochem® |
| Synonyms | 5-(N-(4-Methylphenyl)amino)-2-methyl-4,7-dioxobenzothiazole, Ryuvidine |
| References | |
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| References | Ryu, C.K., et al. 2000. Bioorg. Med. Chem. Lett. 10, 461. |
| Product Information | |
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| CAS number | 265312-55-8 |
| ATP Competitive | N |
| Form | Black-purple solid |
| Hill Formula | C₁₅H₁₂N₂O₂S |
| Chemical formula | C₁₅H₁₂N₂O₂S |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Cdk4 |
| Primary Target IC<sub>50</sub> | 6.0 µM for Cdk4/D1 and > 200 µM for Cdk2/A |
| Purity | ≥90% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 219478-5MG | 04055977218558 |
Documentation
Cdk4 Inhibitor III - CAS 265312-55-8 - Calbiochem SDB
| Titel |
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Cdk4 Inhibitor III - CAS 265312-55-8 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 219478 |
Literatur
| Übersicht |
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| Ryu, C.K., et al. 2000. Bioorg. Med. Chem. Lett. 10, 461. |