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218860 Casein Kinase II Inhibitor VIII - CAS 1361229-76-6 - Calbiochem

The Casein Kinase II Inhibitor VIII controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

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Synonyme: CK2 Inhibitor VIII, DYRK1B Inhibitor, Flt-3 Inhibitor VII, 4-(2-(4-Methoxybenzamido)thiazol-5-yl)benzoic acid

Primary Target: CK2
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218860
Preis & Verfügbarkeit

Übersicht

Key Spec Table

CAS #Empirical Formula
1361229-76-6C₁₈H₁₄N₂O₄S

Preis & Verfügbarkeit

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218860-10MG
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      Description
      OverviewA cell-permeable thiazolamide compound that acts as a potent, reversible, and ATP-competitive inhibitor against casein kinase-2/CK2 (IC50 = 32 and 46 nM against CK2α and CK2α', respectively), as well as DYRK1B and FLt-3 (82% and 76% inhibition, respectively, at 30 nM), while diplaying reduced or little potency toward other targets in a 70-kinase panel selectivity profile study. Shown to effectively block the proliferation of a variety of cancer cells (IC50 = 2.6, 1.6, and 2.4 µM, in A549, HCT116, and MCF-7 cultures, respectively).
      Catalogue Number218860
      Brand Family Calbiochem®
      SynonymsCK2 Inhibitor VIII, DYRK1B Inhibitor, Flt-3 Inhibitor VII, 4-(2-(4-Methoxybenzamido)thiazol-5-yl)benzoic acid
      References
      ReferencesHou, Z., et al. 2012. J. Med. Chem. 55, 2899.
      Product Information
      CAS number1361229-76-6
      FormOff-white solid
      Hill FormulaC₁₈H₁₄N₂O₄S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetCK2
      Primary Target IC<sub>50</sub>32 and 46 nM for CK2&alpha
      Secondary targetDYRK1B, Flt-3
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Bestellnummer GTIN
      218860-10MG 04055977201963