218710 Sigma-AldrichCasein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem
Casein Kinase II Inhibitor III, TBCA, CAS 934358-00-6, is a cell-permeable, potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM).
More>> Casein Kinase II Inhibitor III, TBCA, CAS 934358-00-6, is a cell-permeable, potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM). Less<<SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: (E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid, CKII Inhibitor, TBCA
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 934358-00-6 | C₉H₄Br₄O₂ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 218710-5MG |
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Kunststoffbeutel | 5 mg |
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| Description | |
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| Overview | A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. Nos. 218697 and 218708) and DMAT (Cat. Nos. 218699 and 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induces apoptosis in Jurkat cells (DC50 = 7.7 µM). Also available as a 25 mM solution in DMSO (Cat. No. 218861). |
| Catalogue Number | 218710 |
| Brand Family | Calbiochem® |
| Synonyms | (E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid, CKII Inhibitor, TBCA |
| References | |
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| References | Pagano, M.A., et al. 2006. Chembiochem 8, 129 |
| Product Information | |
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| CAS number | 934358-00-6 |
| ATP Competitive | Y |
| Form | Off-white solid |
| Hill Formula | C₉H₄Br₄O₂ |
| Chemical formula | C₉H₄Br₄O₂ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
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| Application | Casein Kinase II Inhibitor III, TBCA, CAS 934358-00-6, is a cell-permeable, potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM). |
| Biological Information | |
|---|---|
| Primary Target | Casein Kinase II |
| Primary Target IC<sub>50</sub> | 110 nM |
| Primary Target K<sub>i</sub> | 77 nM against Casein Kinase II |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 218710-5MG | 04055977202571 |
Documentation
Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem SDB
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Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 218710 |
Literatur
| Übersicht |
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| Pagano, M.A., et al. 2006. Chembiochem 8, 129 |