196870 Sigma-AldrichBAY 11-7082 - CAS 19542-67-7 - Calbiochem
BAY 11-7082, CAS 19542-67-7, selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IBα (IC50 = 10 µM), resulting in reduced levels of NF-B. and of adhesion molecules.
More>> BAY 11-7082, CAS 19542-67-7, selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IBα (IC50 = 10 µM), resulting in reduced levels of NF-B. and of adhesion molecules. Less<<BAY 11-7082 - CAS 19542-67-7 - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Synonyme: (E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
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| 19542-67-7 | C₁₀H₉NO₂S |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
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| 196870-10MG |
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Glasflasche | 10 mg |
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| Description | |
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| Overview | Potential anti-inflammatory agent that selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IκBα (IC50 = 10 µM), resulting in a decreased expression of NF-κB and of adhesion molecules. Does not affect constitutive IκBα autophosphorylation. Inhibits TNF-α-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. A 100 mM (10 mg/483 µl) solution of BAY 11-7082 (Cat. No. 196871) in DMSO is also available is also available. |
| Catalogue Number | 196870 |
| Brand Family | Calbiochem® |
| Synonyms | (E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile |
| References | |
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| References | Kamthong PJ. and Wu, M-C. 2001. Biochem. J. 356. Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482. Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096. |
| Product Information | |
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| CAS number | 19542-67-7 |
| Form | Off-white solid |
| Hill Formula | C₁₀H₉NO₂S |
| Chemical formula | C₁₀H₉NO₂S |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
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| Primary Target | TNF-α-inducible phosphorylation of IκBα |
| Primary Target IC<sub>50</sub> | 10 µM inhibiting TNF-α-inducible phosphorylation of IκBα |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 196870-10MG | 04055977206562 |
Documentation
BAY 11-7082 - CAS 19542-67-7 - Calbiochem SDB
| Titel |
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BAY 11-7082 - CAS 19542-67-7 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
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| 196870 |
Literatur
| Übersicht |
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| Kamthong PJ. and Wu, M-C. 2001. Biochem. J. 356. Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482. Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096. |
Broschüre
| Titel |
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| Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling |
Literaturstellen
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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