Millipore Sigma Vibrant Logo

189490 Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem

Autophagy Inhibitor, 3-MA, CAS 5142-23-4, is a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis following serum/potassium deprivation.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 3-Methyladenine

View Products on Sigmaaldrich.com
189490
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
5142-23-4C₆H₇N₅

Preis & Verfügbarkeit

Bestellnummer VerfügbarkeitVerpackung St./Pkg. Preis Menge
189490-100MG
Verfügbarkeit wird abgerufen...
—
Eingeschränkte Verfügbarkeit Eingeschränkte Verfügbarkeit
Lieferbar 
Produkt wurde eingestellt
Begrenzter Lagerbestand
Bestätigung der Verfügbarkeit erforderlich
    Restmenge: Angebot folgt
      Restmenge: Angebot folgt
      Bitte erfragen
      Kontakt zum Kundenservice
      Contact Customer Service

      		 Glasflasche 100 mg
      Preis wird abgerufen...
      Preis nicht abrufbar
      Die Mindestmenge muss ein Vielfaches sein von
      Maximum Quantity is
      Bei Bestätigung Weitere Informationen
      Sie haben () gespart
       
      —
      Bitte erfragen
      		 —
      189490-50MG
      Verfügbarkeit wird abgerufen...
      —
      Eingeschränkte Verfügbarkeit Eingeschränkte Verfügbarkeit
      Lieferbar 
      Produkt wurde eingestellt
      Begrenzter Lagerbestand
      Bestätigung der Verfügbarkeit erforderlich
        Restmenge: Angebot folgt
          Restmenge: Angebot folgt
          Bitte erfragen
          Kontakt zum Kundenservice
          Contact Customer Service

          		 Kst.-Ampulle 50 mg
          Preis wird abgerufen...
          Preis nicht abrufbar
          Die Mindestmenge muss ein Vielfaches sein von
          Maximum Quantity is
          Bei Bestätigung Weitere Informationen
          Sie haben () gespart
           
          —
          Bitte erfragen
          		 —
          Description
          OverviewA widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC50 = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos. 440202 and 440204) and Wortmannin (Cat. No. 681675)
          Catalogue Number189490
          Brand Family Calbiochem®
          Synonyms3-Methyladenine
          References
          ReferencesCanu, N., et al. 2005. J. Neurochem. 92, 1228.
          Hirosako, K., et al. 2004. Biochem. Biophys. Res. Commun. 316, 845.
          Beugnet, A., et al. 2003. Biochem. J. 372, 555.
          Eskelinen, E.L., et al. 2002. Traffic 3, 878.
          Petiot, A., et al. 2000. J. Biol. Chem. 275, 992.
          Seglen, P.O. and Gordon, P.B., 1982. Proc. Natl. Acad. Sci. USA 79, 1889.
          Product Information
          CAS number5142-23-4
          FormWhite to faint yellow powder
          Hill FormulaC₆H₇N₅
          Chemical formulaC₆H₇N₅
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationAutophagy Inhibitor, 3-MA, CAS 5142-23-4, is a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis following serum/potassium deprivation.
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Bestellnummer GTIN
          189490-100MG 04055977221831
          189490-50MG 07790788048235

          Documentation

          Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem SDB

          Titel

          Sicherheitsdatenblatt (SDB) 

          Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem Analysenzertifikate

          TitelChargennummer
          189490

          Literatur

          Übersicht
          Canu, N., et al. 2005. J. Neurochem. 92, 1228.
          Hirosako, K., et al. 2004. Biochem. Biophys. Res. Commun. 316, 845.
          Beugnet, A., et al. 2003. Biochem. J. 372, 555.
          Eskelinen, E.L., et al. 2002. Traffic 3, 878.
          Petiot, A., et al. 2000. J. Biol. Chem. 275, 992.
          Seglen, P.O. and Gordon, P.B., 1982. Proc. Natl. Acad. Sci. USA 79, 1889.

          Technische Informationen

          Titel
          LentiBrite™ Lentiviral Biosensors for Fluorescent Cellular Imaging: Analysis of Autophagosome Formation
          Datenblatt

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-May-2012 JSW
          Synonyms3-Methyladenine
          DescriptionA widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC50 = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos. 440202 and 440204) and Wortmannin (Cat. No. 681675)
          FormWhite to faint yellow powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number5142-23-4
          Chemical formulaC₆H₇N₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) or H₂O (5 mg/ml). In applications where high working concentrations are necessary (e.g. 10 mM), the use of a pre-made stock solution may result in the introduction of higher than desired solvent (e.g., DMSO) into the experimental systems. In such cases, it is recommended that the solid compound be weighed out at the time of use and reconstituted directly into the solutions used in the experimental system (buffers, media, etc.). Vortexing may be required for complete solubilization in water.
          Storage Protect from light
          +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesCanu, N., et al. 2005. J. Neurochem. 92, 1228.
          Hirosako, K., et al. 2004. Biochem. Biophys. Res. Commun. 316, 845.
          Beugnet, A., et al. 2003. Biochem. J. 372, 555.
          Eskelinen, E.L., et al. 2002. Traffic 3, 878.
          Petiot, A., et al. 2000. J. Biol. Chem. 275, 992.
          Seglen, P.O. and Gordon, P.B., 1982. Proc. Natl. Acad. Sci. USA 79, 1889.