178273 Sigma-AldrichAphidicolin - CAS 38966-21-1 - Calbiochem
Aphidicolin, CAS 38966-21-1, is a cell-permeable antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase.
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Übersicht
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Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 38966-21-1 | C₂₀H₃₄O₄ |
Preis & Verfügbarkeit
| Bestellnummer | Verfügbarkeit | Verpackung | St./Pkg. | Preis | Menge | |
|---|---|---|---|---|---|---|
| 178273-1MG |
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Kst.-Ampulle | 1 mg |
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| Description | |
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| Overview | A cell-permeable tetracyclic diterpene antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLa S3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3. Also available as a 30 mM solution in DMSO (Cat. No. 504744). |
| Catalogue Number | 178273 |
| Brand Family | Calbiochem® |
| Product Information | |
|---|---|
| CAS number | 38966-21-1 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₂₀H₃₄O₄ |
| Chemical formula | C₂₀H₃₄O₄ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | DNA polymerase α, DNA polymerase δ |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS | |
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| RTECS | PB9185000 |
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| Specifications |
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| Global Trade Item Number | |
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| Bestellnummer | GTIN |
| 178273-1MG | 04055977223163 |
Documentation
Aphidicolin - CAS 38966-21-1 - Calbiochem SDB
| Titel |
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Aphidicolin - CAS 38966-21-1 - Calbiochem Analysenzertifikate
| Titel | Chargennummer |
|---|---|
| 178273 |
Literatur
| Übersicht |
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| Borner, M.M., et al. 1995. Cancer Res. 55, 2122. Poluha, W., et al. 1995. Oncogene 10, 185. Urbani, L., et al. 1995. Exp. Cell Res. 219, 159. Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci. 345, 311. Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909. Hubermann, J.A. 1981. Cell 23, 647. |
Broschüre
| Titel |
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| Caspases and other Apoptosis Related Tools Brochure |
| Tools and Tips for Analyzing Apoptosis |