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07-1352 Anti-acetyl STAT5B (Lys701) Antibody

Detect acetyl STAT5B (Lys701) using this Anti-acetyl STAT5B (Lys701) Antibody validated for use in DB & WB.

Anti-acetyl STAT5B (Lys701) Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: STAT5B UniProt Number: P51692
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07-1352
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HDB, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-1352
      DescriptionAnti-acetyl STAT5B (Lys701) Antibody
      Alternate Names
      • Signal transducer and activator of transcription 5B
      Background InformationSTAT5B (signal transducers and activators of transcription 5b) controls the expression of early response genes and takes part in cytokine signaling. Studies have linked this protein to the inhibition of NFkappaB-mediated signaling. Additional studies have shown an association of STAT5B with regulation of lactation and growth, performance, and control of adipocyte function. Constitutively active STAT5B expression is often observed in a large number of leukemia’s and solid tumors.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Modified and non modified peptides of acetylated and non-acetylated STAT5B protein
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect acetyl STAT5B (Lys701) using this Anti-acetyl STAT5B (Lys701) Antibody validated for use in DB & WB.
      Key Applications
      • Dot Blot
      • Western Blotting
      Application NotesWestern Blot Analysis: A representative lot was used by an independent laboratory in WB. (Ma, L., et al. (2010). Proc Natl Acad Sci U S A. 107(45):19314-19319.)
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human STAT5B acetylated at Lys701.
      EpitopeAcetylated Lys701
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes STAT5B acetylated at Lys701.
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with Human. Other homologies: Rat and Mouse (91% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • STAT5B
      Modifications
      • Acetylation
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.

      SUBUNIT STRUCTURE: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7.

      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note: Translocated into the nucleus in response to phosphorylation (By similarity).

      INVOLVEMENT IN DISEASE: Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, and resistance to hexogeneous hormone therapy.

      SEQUENCE SIMILARITIES: Belongs to the transcription factor STAT family.

      Contains 1 SH2 domain.
      Molecular Weight90 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Dot Blot in modified and non modified peptides of acetylated and non-acetylated STAT5B protein.

      Dot Blot Analysis: 1 µg/mL of this antibody detected STAT5B in modified and non modified peptides of acetylated and non-acetylated STAT5B protein.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      07-1352 04053252520709

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      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies