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ABN410 Anti-ZNF423 Antibody

Anti-ZNF423 Antibody is an antibody against ZNF423 for use in western blotting, IHC (Paraffin) & ICC.

Anti-ZNF423 Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: ZNF423, NPHP14, OAZ UniProt Number: Q2M1K9
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ABN410
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IH(P), ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN410
      DescriptionAnti-ZNF423 Antibody
      Alternate Names
      • Zinc finger protein 423
      • Olf1/EBF-associated zinc finger protein
      • hOAZ
      • Smad- and Olf-interacting zinc finger protein
      • ZFP423
      Background InformationZNF423, also known as Zinc finger protein 423, Olf1/EBF-associated zinc finger protein, hOAZ, or Smad and Olf-interacting zinc finger protein, and encoded by the gene ZNF423/KIAA0760/NPHP14/OAZ, is a transcription factor that can both act as an activator or a repressor depending on the context. ZNF423 plays a central role in BMP signaling and olfactory neurogenesis. ZNF423 acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation. ZNF423 is involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons and it controls the proliferation and differentiation of neural precursors in cerebellar vermis formation. ZNF423 is expressed in many organs including the brain, lung, skeletal muscle and heart in both fetal and adult states. Defects in ZNF423 cause the genetic kidney disease nephronophthisis and the neurological disorder called Joubert syndrome.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-ZNF423 Antibody is an antibody against ZNF423 for use in western blotting, IHC (Paraffin) & ICC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      • Immunocytochemistry
      Application NotesImmunohistochemistry Analysis: A 1:500 and a 1:50 dilution from a representative lot detected ZNF423 in human and rat cerebellum tissues, respectively.

      Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected ZNF423 in human thalamus and hippocampus tissues.

      Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected ZNF423 in NIH/3T3 cells.

      DyLight® is a registered trademark of Thermo Fisher Scientific.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to a region near the C-terminus of human ZNF423. (Note: The immunogen contains 93% sequence homology with bovine.)
      EpitopeNear C-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ZNF423
      • NPHP14
      • OAZ
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~125 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse P7 brain tissue lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected ZNF423 in 10 µg of mouse P7 brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABN410 04053252959202