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ABC499 Anti-Tropomyosin Antibody, isoforms 5a, 5b, Br2, Br3

This Anti-Tropomyosin Antibody, isoforms 5a, 5b, Br2, Br3 is validated for use in western blotting, IHC & ICC for the detection of Tropomyosin.

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Research Category: Apoptosis & Cancer Research Sub-Category: Cytoskeleton Gene Symbol: Tpm1, Tpm-1, Tpma UniProt Number: P58771
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ABC499
50 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, MWB, IHC, ICCShAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC499
      DescriptionAnti-Tropomyosin Antibody, isoforms 5a, 5b, Br2, Br3
      Alternate Names
      • Tropomyosin alpha-1 chain
      • Alpha-tropomyosin
      • Tropomyosin-1
      Background InformationTropomyosin, also known as Tropomyosin alpha-1 chain or Alpha-tropomyosin, or Tropomyosin-1, and encoded by the gene Tpm1/Tpm-1/TPMA, is one chain of the heterodimer complex of tropomyosin that binds to actin in muscle and non-muscle cells and plays a central role in the troponin complex in muscle regulating the calcium dependent vertebrate striated muscle contraction. In non muscle cells tropomyosin assists in cell structure by stabilizing the actin cytoskeleton filaments. Tropomyosin is localized to the cytoplasm. Tropomyosin is expressed in cardiac and skeletal muscle cells as well as non-muscle cells. Defects in Tropomyosin may be associated with Cardiomyopathy, familial hypertrophic 3 (CMH3)] disease. It is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter-and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified sheep polyclonal in pH 7.0 buffer containing 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Tropomyosin Antibody, isoforms 5a, 5b, Br2, Br3 is validated for use in western blotting, IHC & ICC for the detection of Tropomyosin.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunocytochemistry
      Application NotesWestern Blotting Analysis: 1 µg/mL from a representative lot detected Tropomyosin in 10 µg of rat brain, human brain, mouse cerebellum, and mouse hypothalamus tissue lysate.

      Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Tropomyosin in human prostate cancer tissue and human breast cancer tissue.

      Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Tropomyosin in B35 cells (Schevzov, G., et al. (2011). Bioarchitecture. 1(4):135-164.).
      Biological Information
      ImmunogenLinear peptide corresponding to exon 1b of mouse Tropomyosin.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostSheep
      SpecificityThis antibody specifically recognizes isoforms 5a, 5b, Br2, and Br3 of Tropomyosin.
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Tpm1
      • Tpm-1
      • Tpma
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~32 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse brain tissue lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected Tropomyosin in 10 µg of mouse brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABC499 04053252944826