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MABN224 Anti-Thorase Antibody, clone 9G7.1

This Anti-Thorase Antibody, clone 9G7.1 is validated for use in Western Blotting for the detection of Thorase.

Anti-Thorase Antibody, clone 9G7.1: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: ATAD1, FNP001 UniProt Number: Q8NBU5
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MABN224
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN224
      DescriptionAnti-Thorase Antibody, clone 9G7.1
      Alternate Names
      • ATPase family AAA domain-containing protein 1
      • Thorase
      Background InformationThorase is an ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR). Thorase thus helps mediate synaptic plasticity and learning and memory. Thorase expression is required for NMDA-stimulated AMPAR internalization and for the inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane as both of these require ATP processing by Thorase. Thorase is vital for keeping in balance the molecular construction-deconstruction cycle that is required for memory formation. Thorase is one of many AAA+ ATPases that drive the assembly of proteins needed to form specialized receptors at the surfaces of synapses. These receptors are stimulated by neighboring neurons, setting up the signaling and answering connections vital to brain function. Thorase regulates the all-important complementary process of receptor disassembly at synapses, which ultimately tamps down signaling. Thorase is a postsynaptic localized protein, and also is associated with the peroxisome and cell junctions and synapses. Thorase is expressed in the brain and testis primarily.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Thorase Antibody, clone 9G7.1 is validated for use in Western Blotting for the detection of Thorase.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected Thorase in 10 µg of human brain tissue lysate.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Thorase.
      Clone9G7.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Mouse based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ATAD1
      • FNP001
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~41 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human lymph node tissue lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Thorase in 10 µg of human lymph node tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABN224 04053252984853