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ABN421 Anti-Senataxin (OY11) Antibody

This Anti-Senataxin (OY11) Antibody is validated for use in Western Blotting and Immunoprecipitation for the detection of Senataxin .

Anti-Senataxin (OY11) Antibody : SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: SETX, ALS4, KIAA0625, SCAR1 UniProt Number: Q7Z333
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ABN421
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IPRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN421
      DescriptionAnti-Senataxin (OY11) Antibody
      Alternate Names
      • Probable helicase senataxin
      • Senataxin (OY11)
      • Amyotrophic lateral sclerosis 4 protein
      • SEN1 homolog
      • Senataxin
      Background InformationProbable helicase senataxin (UniProt Q7Z333; also known as Amyotrophic lateral sclerosis 4 protein, SEN1 homolog) is encoded by the SETX (also known as ALS4, AOA2, SCAR1, bA479K20.2) gene (Gene ID 23064) in human. Senataxin is implicated in both genome and RNA transcriptome homeostasis. Senataxin contains a helicase domain for mediating RNA interaction and an N-terminal domain for critical protein interactions. Senataxin is reported to colocalize with DNA repair proteins, including the DNA damage response protein 53BP1, at distinct nuclear foci in S/G2-phase human cells, and the number of these foci increases in response to impaired DNA replication or DNA damage. Senataxin is shown to resolve RNA/DNA hybrids (R loops) that arise during transcription, which can lead to genome instability unless they are resolved efficiently.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Senataxin (OY11) Antibody is validated for use in Western Blotting and Immunoprecipitation for the detection of Senataxin .
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      Application NotesImmunoprecipitation Analysis: 2 µg from a representative lot immunoprecipitated Senataxin from HeLa, U2OS, and HEK293 cell lysates (Courtesy of Dr. Kanagaraj Radhakrishnan and Dr. Stephen C. West, The Francis Crick Institute, London, UK).
      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Senataxin and siRNA-mediated Senataxin downregulation in HEK293 cells (Courtesy of Dr. Kanagaraj Radhakrishnan and Dr. Stephen C. West, The Francis Crick Institute, London, UK).
      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Flag-tagged Senataxin in anti-Flag immunoprecipitates from transfected HEK293 cells expressing Flag-tagged Senataxin (Courtesy of Dr. Kanagaraj Radhakrishnan and Dr. Stephen C. West, The Francis Crick Institute, London, UK).
      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Senataxin in HEK293 cell lysates (Courtesy of Dr. Kanagaraj Radhakrishnan and Dr. Stephen C. West, The Francis Crick Institute, London, UK).
      Biological Information
      ImmunogenA mixture of four KLH-conjugated linear peptides corresponding to sequences from both N- and C-terminal halves of human senataxin.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SETX
      • ALS4
      • KIAA0625
      • SCAR1
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~300 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HUVEC cell lysate.

      Western Blotting Analysis: 0.2 µg/mL of this antibody detected Senataxin in 10 µg of HUVEC lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABN421 04055977297355

      Documentation

      Anti-Senataxin (OY11) Antibody SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Anti-Senataxin (OY11) Antibody Analysenzertifikate

      TitelChargennummer
      Anti-Senataxin (OY11) - 3172408 3172408
      Anti-Senataxin (OY11) - 3204864 3204864
      Anti-Senataxin (OY11) - 3425419 3425419
      Anti-Senataxin (OY11) - 3934809 3934809
      Anti-Senataxin (OY11) -Q2618545 Q2618545

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